Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

Cardiac failure is a leading cause of age-related death, though its root cause remains unknown. Mounting evidence implicates a decline in mitochondrial function due to increased opening of the mitochondrial permeability transition pore (mPTP). Here we report that the NAD(+)-dependent deacetylase SIR...

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Detalles Bibliográficos
Autores principales: Hafner, Angela V., Dai, Jing, Gomes, Ana P., Xiao, Chun-Yang, Palmeira, Carlos M., Rosenzweig, Anthony, Sinclair, David A.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034180/
https://www.ncbi.nlm.nih.gov/pubmed/21212461

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