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RTX proteins: a highly diverse family secreted by a common mechanism

Repeats-in-toxin (RTX) exoproteins of Gram-negative bacteria form a steadily growing family of proteins with diverse biological functions. Their common feature is the unique mode of export across the bacterial envelope via the type I secretion system and the characteristic, typically nonapeptide, gl...

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Autores principales: Linhartová, Irena, Bumba, Ladislav, Mašín, Jiří, Basler, Marek, Osička, Radim, Kamanová, Jana, Procházková, Kateřina, Adkins, Irena, Hejnová-Holubová, Jana, Sadílková, Lenka, Morová, Jana, Šebo, Peter
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034196/
https://www.ncbi.nlm.nih.gov/pubmed/20528947
http://dx.doi.org/10.1111/j.1574-6976.2010.00231.x
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author Linhartová, Irena
Bumba, Ladislav
Mašín, Jiří
Basler, Marek
Osička, Radim
Kamanová, Jana
Procházková, Kateřina
Adkins, Irena
Hejnová-Holubová, Jana
Sadílková, Lenka
Morová, Jana
Šebo, Peter
author_facet Linhartová, Irena
Bumba, Ladislav
Mašín, Jiří
Basler, Marek
Osička, Radim
Kamanová, Jana
Procházková, Kateřina
Adkins, Irena
Hejnová-Holubová, Jana
Sadílková, Lenka
Morová, Jana
Šebo, Peter
author_sort Linhartová, Irena
collection PubMed
description Repeats-in-toxin (RTX) exoproteins of Gram-negative bacteria form a steadily growing family of proteins with diverse biological functions. Their common feature is the unique mode of export across the bacterial envelope via the type I secretion system and the characteristic, typically nonapeptide, glycine- and aspartate-rich repeats binding Ca(2+) ions. In this review, we summarize the current state of knowledge on the organization of rtx loci and on the biological and biochemical activities of therein encoded proteins. Applying several types of bioinformatic screens on the steadily growing set of sequenced bacterial genomes, over 1000 RTX family members were detected, with the biological functions of most of them remaining to be characterized. Activities of the so far characterized RTX family members are then discussed and classified according to functional categories, ranging from the historically first characterized pore-forming RTX leukotoxins, through the large multifunctional enzymatic toxins, bacteriocins, nodulation proteins, surface layer proteins, up to secreted hydrolytic enzymes exhibiting metalloprotease or lipase activities of industrial interest.
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spelling pubmed-30341962011-02-15 RTX proteins: a highly diverse family secreted by a common mechanism Linhartová, Irena Bumba, Ladislav Mašín, Jiří Basler, Marek Osička, Radim Kamanová, Jana Procházková, Kateřina Adkins, Irena Hejnová-Holubová, Jana Sadílková, Lenka Morová, Jana Šebo, Peter FEMS Microbiol Rev Review Articles Repeats-in-toxin (RTX) exoproteins of Gram-negative bacteria form a steadily growing family of proteins with diverse biological functions. Their common feature is the unique mode of export across the bacterial envelope via the type I secretion system and the characteristic, typically nonapeptide, glycine- and aspartate-rich repeats binding Ca(2+) ions. In this review, we summarize the current state of knowledge on the organization of rtx loci and on the biological and biochemical activities of therein encoded proteins. Applying several types of bioinformatic screens on the steadily growing set of sequenced bacterial genomes, over 1000 RTX family members were detected, with the biological functions of most of them remaining to be characterized. Activities of the so far characterized RTX family members are then discussed and classified according to functional categories, ranging from the historically first characterized pore-forming RTX leukotoxins, through the large multifunctional enzymatic toxins, bacteriocins, nodulation proteins, surface layer proteins, up to secreted hydrolytic enzymes exhibiting metalloprotease or lipase activities of industrial interest. Blackwell Publishing Ltd 2010-11 /pmc/articles/PMC3034196/ /pubmed/20528947 http://dx.doi.org/10.1111/j.1574-6976.2010.00231.x Text en Journal compilation © 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. No claim to original Czech Republic government works http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Review Articles
Linhartová, Irena
Bumba, Ladislav
Mašín, Jiří
Basler, Marek
Osička, Radim
Kamanová, Jana
Procházková, Kateřina
Adkins, Irena
Hejnová-Holubová, Jana
Sadílková, Lenka
Morová, Jana
Šebo, Peter
RTX proteins: a highly diverse family secreted by a common mechanism
title RTX proteins: a highly diverse family secreted by a common mechanism
title_full RTX proteins: a highly diverse family secreted by a common mechanism
title_fullStr RTX proteins: a highly diverse family secreted by a common mechanism
title_full_unstemmed RTX proteins: a highly diverse family secreted by a common mechanism
title_short RTX proteins: a highly diverse family secreted by a common mechanism
title_sort rtx proteins: a highly diverse family secreted by a common mechanism
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034196/
https://www.ncbi.nlm.nih.gov/pubmed/20528947
http://dx.doi.org/10.1111/j.1574-6976.2010.00231.x
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