Alzheimer's Disease and Anesthesia

Cognitive disorders such as postoperative cognitive dysfunction, confusion, and delirium, are common following anesthesia in the elderly, with symptoms persisting for months or years in some patients. Alzheimer's disease (AD) patients appear to be particularly at risk of cognitive deterioration...

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Detalles Bibliográficos
Autores principales: Papon, Marie-Amélie, Whittington, Robert A., El-Khoury, Noura B., Planel, Emmanuel
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034231/
https://www.ncbi.nlm.nih.gov/pubmed/21344011
http://dx.doi.org/10.3389/fnins.2010.00272
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author Papon, Marie-Amélie
Whittington, Robert A.
El-Khoury, Noura B.
Planel, Emmanuel
author_facet Papon, Marie-Amélie
Whittington, Robert A.
El-Khoury, Noura B.
Planel, Emmanuel
author_sort Papon, Marie-Amélie
collection PubMed
description Cognitive disorders such as postoperative cognitive dysfunction, confusion, and delirium, are common following anesthesia in the elderly, with symptoms persisting for months or years in some patients. Alzheimer's disease (AD) patients appear to be particularly at risk of cognitive deterioration following anesthesia, and some studies suggest that exposure to anesthetics may increase the risk of AD. Here, we review the literature linking anesthesia to AD, with a focus on the biochemical consequences of anesthetic exposure on AD pathogenic pathways.
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spelling pubmed-30342312011-02-22 Alzheimer's Disease and Anesthesia Papon, Marie-Amélie Whittington, Robert A. El-Khoury, Noura B. Planel, Emmanuel Front Neurosci Neuroscience Cognitive disorders such as postoperative cognitive dysfunction, confusion, and delirium, are common following anesthesia in the elderly, with symptoms persisting for months or years in some patients. Alzheimer's disease (AD) patients appear to be particularly at risk of cognitive deterioration following anesthesia, and some studies suggest that exposure to anesthetics may increase the risk of AD. Here, we review the literature linking anesthesia to AD, with a focus on the biochemical consequences of anesthetic exposure on AD pathogenic pathways. Frontiers Research Foundation 2011-01-31 /pmc/articles/PMC3034231/ /pubmed/21344011 http://dx.doi.org/10.3389/fnins.2010.00272 Text en Copyright © 2011 Papon, Whittington, El-Khoury and Planel. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and Frontiers Media SA, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Papon, Marie-Amélie
Whittington, Robert A.
El-Khoury, Noura B.
Planel, Emmanuel
Alzheimer's Disease and Anesthesia
title Alzheimer's Disease and Anesthesia
title_full Alzheimer's Disease and Anesthesia
title_fullStr Alzheimer's Disease and Anesthesia
title_full_unstemmed Alzheimer's Disease and Anesthesia
title_short Alzheimer's Disease and Anesthesia
title_sort alzheimer's disease and anesthesia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034231/
https://www.ncbi.nlm.nih.gov/pubmed/21344011
http://dx.doi.org/10.3389/fnins.2010.00272
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