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Human Monocytotropic Ehrlichiosis, Missouri

To determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an outpatient primary care clinic in Cape Girardeau, Missouri. One hundred and two patie...

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Autores principales: Olano, Juan P., Masters, Edwin, Hogrefe, Wayne, Walker, David H.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034327/
https://www.ncbi.nlm.nih.gov/pubmed/14720399
http://dx.doi.org/10.3201/eid0912.020733
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author Olano, Juan P.
Masters, Edwin
Hogrefe, Wayne
Walker, David H.
author_facet Olano, Juan P.
Masters, Edwin
Hogrefe, Wayne
Walker, David H.
author_sort Olano, Juan P.
collection PubMed
description To determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an outpatient primary care clinic in Cape Girardeau, Missouri. One hundred and two patients with a history of fever for 3 days (>37.7°C), tick bite or exposure, and no other infectious disease diagnosis were enrolled between March 1997 and December 1999. HME was diagnosed in 29 patients by indirect immunofluorescent antibody assay and polymerase chain reaction (PCR). Clinical and laboratory manifestations included fever (100%), headache (72%), myalgia or arthralgia (69%), chills (45%), weakness (38%), nausea (38%), leukopenia (60%), thrombocytopenia (56%), and elevated aspartate aminotransferase level (52%). Hospitalization occurred in 41% of case-patients. PCR sensitivity was 56%; specificity, 100%. HME is a prevalent, potentially severe disease in southeastern Missouri that often requires hospitalization. Because clinical presentation of HME is nonspecific, PCR is useful in the diagnosis of acute HME.
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spelling pubmed-30343272011-02-10 Human Monocytotropic Ehrlichiosis, Missouri Olano, Juan P. Masters, Edwin Hogrefe, Wayne Walker, David H. Emerg Infect Dis Research To determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an outpatient primary care clinic in Cape Girardeau, Missouri. One hundred and two patients with a history of fever for 3 days (>37.7°C), tick bite or exposure, and no other infectious disease diagnosis were enrolled between March 1997 and December 1999. HME was diagnosed in 29 patients by indirect immunofluorescent antibody assay and polymerase chain reaction (PCR). Clinical and laboratory manifestations included fever (100%), headache (72%), myalgia or arthralgia (69%), chills (45%), weakness (38%), nausea (38%), leukopenia (60%), thrombocytopenia (56%), and elevated aspartate aminotransferase level (52%). Hospitalization occurred in 41% of case-patients. PCR sensitivity was 56%; specificity, 100%. HME is a prevalent, potentially severe disease in southeastern Missouri that often requires hospitalization. Because clinical presentation of HME is nonspecific, PCR is useful in the diagnosis of acute HME. Centers for Disease Control and Prevention 2003-12 /pmc/articles/PMC3034327/ /pubmed/14720399 http://dx.doi.org/10.3201/eid0912.020733 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Olano, Juan P.
Masters, Edwin
Hogrefe, Wayne
Walker, David H.
Human Monocytotropic Ehrlichiosis, Missouri
title Human Monocytotropic Ehrlichiosis, Missouri
title_full Human Monocytotropic Ehrlichiosis, Missouri
title_fullStr Human Monocytotropic Ehrlichiosis, Missouri
title_full_unstemmed Human Monocytotropic Ehrlichiosis, Missouri
title_short Human Monocytotropic Ehrlichiosis, Missouri
title_sort human monocytotropic ehrlichiosis, missouri
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034327/
https://www.ncbi.nlm.nih.gov/pubmed/14720399
http://dx.doi.org/10.3201/eid0912.020733
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