Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia

The progression of Pneumocystis carinii pneumonia was temporally monitored and quantified by real-time polymerase chain reaction of P. carinii–specific DNA in oral swabs and lung homogenates from infected rats. DNA levels correlated with the number of P. carinii organisms in the rats’ lungs, as enum...

Descripción completa

Detalles Bibliográficos
Autores principales: Linke, Michael J., Rebholz, Sandy, Collins, Margaret, Tanaka, Reiko, Cushion, Melanie T.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2003
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034349/
https://www.ncbi.nlm.nih.gov/pubmed/14720405
http://dx.doi.org/10.3201/eid0912.030270
Descripción
Sumario:The progression of Pneumocystis carinii pneumonia was temporally monitored and quantified by real-time polymerase chain reaction of P. carinii–specific DNA in oral swabs and lung homogenates from infected rats. DNA levels correlated with the number of P. carinii organisms in the rats’ lungs, as enumerated by microscopic methods. This report is the first of a noninvasive, antemortem method that can be used to monitor infection in a host over time.

Ejemplares similares