Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia

The progression of Pneumocystis carinii pneumonia was temporally monitored and quantified by real-time polymerase chain reaction of P. carinii–specific DNA in oral swabs and lung homogenates from infected rats. DNA levels correlated with the number of P. carinii organisms in the rats’ lungs, as enum...

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Detalles Bibliográficos
Autores principales: Linke, Michael J., Rebholz, Sandy, Collins, Margaret, Tanaka, Reiko, Cushion, Melanie T.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2003
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034349/
https://www.ncbi.nlm.nih.gov/pubmed/14720405
http://dx.doi.org/10.3201/eid0912.030270
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author Linke, Michael J.
Rebholz, Sandy
Collins, Margaret
Tanaka, Reiko
Cushion, Melanie T.
author_facet Linke, Michael J.
Rebholz, Sandy
Collins, Margaret
Tanaka, Reiko
Cushion, Melanie T.
author_sort Linke, Michael J.
collection PubMed
description The progression of Pneumocystis carinii pneumonia was temporally monitored and quantified by real-time polymerase chain reaction of P. carinii–specific DNA in oral swabs and lung homogenates from infected rats. DNA levels correlated with the number of P. carinii organisms in the rats’ lungs, as enumerated by microscopic methods. This report is the first of a noninvasive, antemortem method that can be used to monitor infection in a host over time.
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spelling pubmed-30343492011-02-10 Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia Linke, Michael J. Rebholz, Sandy Collins, Margaret Tanaka, Reiko Cushion, Melanie T. Emerg Infect Dis Dispatch The progression of Pneumocystis carinii pneumonia was temporally monitored and quantified by real-time polymerase chain reaction of P. carinii–specific DNA in oral swabs and lung homogenates from infected rats. DNA levels correlated with the number of P. carinii organisms in the rats’ lungs, as enumerated by microscopic methods. This report is the first of a noninvasive, antemortem method that can be used to monitor infection in a host over time. Centers for Disease Control and Prevention 2003-12 /pmc/articles/PMC3034349/ /pubmed/14720405 http://dx.doi.org/10.3201/eid0912.030270 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Linke, Michael J.
Rebholz, Sandy
Collins, Margaret
Tanaka, Reiko
Cushion, Melanie T.
Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
title Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
title_full Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
title_fullStr Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
title_full_unstemmed Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
title_short Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
title_sort noninvasive method for monitoring pneumocystis carinii pneumonia
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034349/
https://www.ncbi.nlm.nih.gov/pubmed/14720405
http://dx.doi.org/10.3201/eid0912.030270
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AT collinsmargaret noninvasivemethodformonitoringpneumocystiscariniipneumonia
AT tanakareiko noninvasivemethodformonitoringpneumocystiscariniipneumonia
AT cushionmelaniet noninvasivemethodformonitoringpneumocystiscariniipneumonia

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