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Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia

BACKGROUND: A sizeable body of data demonstrates that membrane ICAM-1 (mICAM-1) plays a significant role in host defense in a site-specific fashion. On the pulmonary vascular endothelium, mICAM-1 is necessary for normal leukocyte recruitment during acute inflammation. On alveolar epithelial cells (A...

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Detalles Bibliográficos
Autores principales:	Mendez, Michael P, Monroy, Yeni K, Du, Ming, Preston, Angela M, Tolle, Leslie, Lin, Yujing, VanDussen, Kelli L, Samuelson, Linda C, Standiford, Theodore J, Curtis, Jeffery L, Beck, James M, Christensen, Paul J, Paine, Robert
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034680/ https://www.ncbi.nlm.nih.gov/pubmed/21247482 http://dx.doi.org/10.1186/1465-9921-12-12

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