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Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study
OBJECTIVES: To evaluate the performance of diffusion-weighted MRI (DWI) in addition to T2-weighted (T2W) MRI for nodal restaging after chemoradiation in rectal cancer. METHODS: Thirty patients underwent chemoradiation followed by MRI (1.5 T) and surgery. Imaging consisted of T2W-MRI and DWI (b0, 500...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034880/ https://www.ncbi.nlm.nih.gov/pubmed/20730540 http://dx.doi.org/10.1007/s00330-010-1937-x |
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author | Lambregts, Doenja M. J. Maas, Monique Riedl, Robert G. Bakers, Frans C. H. Verwoerd, Jan L. Kessels, Alfons G. H. Lammering, Guido Boetes, Carla Beets, Geerard L. Beets-Tan, Regina G. H. |
author_facet | Lambregts, Doenja M. J. Maas, Monique Riedl, Robert G. Bakers, Frans C. H. Verwoerd, Jan L. Kessels, Alfons G. H. Lammering, Guido Boetes, Carla Beets, Geerard L. Beets-Tan, Regina G. H. |
author_sort | Lambregts, Doenja M. J. |
collection | PubMed |
description | OBJECTIVES: To evaluate the performance of diffusion-weighted MRI (DWI) in addition to T2-weighted (T2W) MRI for nodal restaging after chemoradiation in rectal cancer. METHODS: Thirty patients underwent chemoradiation followed by MRI (1.5 T) and surgery. Imaging consisted of T2W-MRI and DWI (b0, 500, 1000). On T2W-MRI, nodes were scored as benign/malignant by two independent readers (R1, R2). Mean apparent diffusion coefficient (ADC) was measured for each node. Diagnostic performance was compared for T2W-MRI, ADC and T2W+ADC, using a per lesion histological validation. RESULTS: ADC was higher for the malignant nodes (1.43 ± 0.38 vs 1.19 ± 0.27 *10(−3) mm(2)/s, p < 0.001). Area under the ROC curve/sensitivity/specificity were 0.88/65%/93% (R1) and 0.95/71%/91% (R2) using T2W-MRI; 0.66/53%/82% using ADC (mean of two readers); and 0.91/56%/98% (R1) and 0.96/56%/99% (R2) using T2W+ADC. There was no significant difference between T2W-MRI and T2W+ADC. Interobserver reproducibility was good for T2W-MRI (κ0.73) and ADC (intraclass correlation coefficient 0.77). CONCLUSIONS: After chemoradiation, ADC measurements may have potential for nodal characterisation, but DWI on its own is not reliable. Addition of DWI to T2W-MRI does not improve accuracy and T2W-MRI is already sufficiently accurate. |
format | Text |
id | pubmed-3034880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-30348802011-03-16 Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study Lambregts, Doenja M. J. Maas, Monique Riedl, Robert G. Bakers, Frans C. H. Verwoerd, Jan L. Kessels, Alfons G. H. Lammering, Guido Boetes, Carla Beets, Geerard L. Beets-Tan, Regina G. H. Eur Radiol Oncology OBJECTIVES: To evaluate the performance of diffusion-weighted MRI (DWI) in addition to T2-weighted (T2W) MRI for nodal restaging after chemoradiation in rectal cancer. METHODS: Thirty patients underwent chemoradiation followed by MRI (1.5 T) and surgery. Imaging consisted of T2W-MRI and DWI (b0, 500, 1000). On T2W-MRI, nodes were scored as benign/malignant by two independent readers (R1, R2). Mean apparent diffusion coefficient (ADC) was measured for each node. Diagnostic performance was compared for T2W-MRI, ADC and T2W+ADC, using a per lesion histological validation. RESULTS: ADC was higher for the malignant nodes (1.43 ± 0.38 vs 1.19 ± 0.27 *10(−3) mm(2)/s, p < 0.001). Area under the ROC curve/sensitivity/specificity were 0.88/65%/93% (R1) and 0.95/71%/91% (R2) using T2W-MRI; 0.66/53%/82% using ADC (mean of two readers); and 0.91/56%/98% (R1) and 0.96/56%/99% (R2) using T2W+ADC. There was no significant difference between T2W-MRI and T2W+ADC. Interobserver reproducibility was good for T2W-MRI (κ0.73) and ADC (intraclass correlation coefficient 0.77). CONCLUSIONS: After chemoradiation, ADC measurements may have potential for nodal characterisation, but DWI on its own is not reliable. Addition of DWI to T2W-MRI does not improve accuracy and T2W-MRI is already sufficiently accurate. Springer-Verlag 2010-08-22 2011 /pmc/articles/PMC3034880/ /pubmed/20730540 http://dx.doi.org/10.1007/s00330-010-1937-x Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Oncology Lambregts, Doenja M. J. Maas, Monique Riedl, Robert G. Bakers, Frans C. H. Verwoerd, Jan L. Kessels, Alfons G. H. Lammering, Guido Boetes, Carla Beets, Geerard L. Beets-Tan, Regina G. H. Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study |
title | Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study |
title_full | Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study |
title_fullStr | Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study |
title_full_unstemmed | Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study |
title_short | Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study |
title_sort | value of adc measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034880/ https://www.ncbi.nlm.nih.gov/pubmed/20730540 http://dx.doi.org/10.1007/s00330-010-1937-x |
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