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Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface

The mycobacterial PE/PPE proteins have attracted much interest since their formal identification just over a decade ago. It has been widely speculated that these proteins may play a role in evasion of host immune responses, possibly via antigenic variation. Although a cohesive understanding of their...

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Detalles Bibliográficos
Autor principal: Sampson, Samantha L.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034920/
https://www.ncbi.nlm.nih.gov/pubmed/21318182
http://dx.doi.org/10.1155/2011/497203
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author Sampson, Samantha L.
author_facet Sampson, Samantha L.
author_sort Sampson, Samantha L.
collection PubMed
description The mycobacterial PE/PPE proteins have attracted much interest since their formal identification just over a decade ago. It has been widely speculated that these proteins may play a role in evasion of host immune responses, possibly via antigenic variation. Although a cohesive understanding of their function(s) has yet to be established, emerging data increasingly supports a role for the PE/PPE proteins at multiple levels of the infectious process. This paper will delineate salient features of the families revealed by comparative genomics, bioinformatic analyses and genome-wide screening approaches and will summarise existing knowledge of subcellular localization, secretion pathways, and protein structure. These characteristics will be considered in light of findings on innate and adaptive host responses to PE/PPE proteins, and we will review the increasing body of data on B and T cell recognition of these proteins. Finally, we will consider how current knowledge and future explorations may contribute to a more comprehensive understanding of these intriguing proteins and their involvement in host pathogen interactions. Ultimately this information could underpin future intervention strategies, for example, in the area of new and improved diagnostic tools and vaccine candidates.
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spelling pubmed-30349202011-02-11 Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface Sampson, Samantha L. Clin Dev Immunol Review Article The mycobacterial PE/PPE proteins have attracted much interest since their formal identification just over a decade ago. It has been widely speculated that these proteins may play a role in evasion of host immune responses, possibly via antigenic variation. Although a cohesive understanding of their function(s) has yet to be established, emerging data increasingly supports a role for the PE/PPE proteins at multiple levels of the infectious process. This paper will delineate salient features of the families revealed by comparative genomics, bioinformatic analyses and genome-wide screening approaches and will summarise existing knowledge of subcellular localization, secretion pathways, and protein structure. These characteristics will be considered in light of findings on innate and adaptive host responses to PE/PPE proteins, and we will review the increasing body of data on B and T cell recognition of these proteins. Finally, we will consider how current knowledge and future explorations may contribute to a more comprehensive understanding of these intriguing proteins and their involvement in host pathogen interactions. Ultimately this information could underpin future intervention strategies, for example, in the area of new and improved diagnostic tools and vaccine candidates. Hindawi Publishing Corporation 2011 2011-01-26 /pmc/articles/PMC3034920/ /pubmed/21318182 http://dx.doi.org/10.1155/2011/497203 Text en Copyright © 2011 Samantha L. Sampson. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sampson, Samantha L.
Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
title Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
title_full Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
title_fullStr Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
title_full_unstemmed Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
title_short Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
title_sort mycobacterial pe/ppe proteins at the host-pathogen interface
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034920/
https://www.ncbi.nlm.nih.gov/pubmed/21318182
http://dx.doi.org/10.1155/2011/497203
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