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Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters
It is widely accepted that the conversion of the soluble, nontoxic amyloid β-protein (Aβ) monomer to aggregated toxic Aβ rich in β-sheet structures is central to the development of Alzheimer's disease. However, the mechanism of the abnormal aggregation of Aβ in vivo is not well understood. Accu...
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| Formato: | Texto |
| Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034960/ https://www.ncbi.nlm.nih.gov/pubmed/21318142 http://dx.doi.org/10.4061/2011/956104 |