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Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels

To evaluate the relationship between circulating adiponectin and insulin sensitivity in patients with hyperthyroid Graves' disease, we studied 19 adult patients with this disease and 19 age- and sex-matched euthyroid controls. All hyperthyroid patients were treated with antithyroid drugs and we...

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Autores principales: Chu, Chih-Hsun, Lam, Hing-Chung, Lee, Jenn-Kuen, Lu, Chih-Chen, Sun, Chun-Chin, Wang, Mei-Chun, Chuang, Ming-Ju
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034962/
https://www.ncbi.nlm.nih.gov/pubmed/21318144
http://dx.doi.org/10.4061/2011/194721
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author Chu, Chih-Hsun
Lam, Hing-Chung
Lee, Jenn-Kuen
Lu, Chih-Chen
Sun, Chun-Chin
Wang, Mei-Chun
Chuang, Ming-Ju
author_facet Chu, Chih-Hsun
Lam, Hing-Chung
Lee, Jenn-Kuen
Lu, Chih-Chen
Sun, Chun-Chin
Wang, Mei-Chun
Chuang, Ming-Ju
author_sort Chu, Chih-Hsun
collection PubMed
description To evaluate the relationship between circulating adiponectin and insulin sensitivity in patients with hyperthyroid Graves' disease, we studied 19 adult patients with this disease and 19 age- and sex-matched euthyroid controls. All hyperthyroid patients were treated with antithyroid drugs and were re-evaluated after thyroid function normalized. Before antithyroid treatment, the adiponectin plasma concentrations were not different comparing with those in control group. The adiponectin levels remained unchanged after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) in hyperthyroid group was higher before treatment than after treatment. There was no significant difference in serum glucose and insulin levels between hyperthyroid and control groups and in the hyperthyroid group before and after treatment. BMI-adjusted adiponectin levels were not different among three groups. On the other hand, BMI-adjusted insulin levels and HOMA-IR values were significantly decreased after management of hyperthyroidism. Pearson's correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels. However, adiponectin did not correlate with T3, FT4, insulin, HOMA-IR and thyrotropin receptor autoantibody (TRAb) levels. In conclusion, insulin resistance associated with hyperthyroidism is not mediated by the levels of plasma adiponectin.
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spelling pubmed-30349622011-02-11 Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels Chu, Chih-Hsun Lam, Hing-Chung Lee, Jenn-Kuen Lu, Chih-Chen Sun, Chun-Chin Wang, Mei-Chun Chuang, Ming-Ju J Thyroid Res Research Article To evaluate the relationship between circulating adiponectin and insulin sensitivity in patients with hyperthyroid Graves' disease, we studied 19 adult patients with this disease and 19 age- and sex-matched euthyroid controls. All hyperthyroid patients were treated with antithyroid drugs and were re-evaluated after thyroid function normalized. Before antithyroid treatment, the adiponectin plasma concentrations were not different comparing with those in control group. The adiponectin levels remained unchanged after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) in hyperthyroid group was higher before treatment than after treatment. There was no significant difference in serum glucose and insulin levels between hyperthyroid and control groups and in the hyperthyroid group before and after treatment. BMI-adjusted adiponectin levels were not different among three groups. On the other hand, BMI-adjusted insulin levels and HOMA-IR values were significantly decreased after management of hyperthyroidism. Pearson's correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels. However, adiponectin did not correlate with T3, FT4, insulin, HOMA-IR and thyrotropin receptor autoantibody (TRAb) levels. In conclusion, insulin resistance associated with hyperthyroidism is not mediated by the levels of plasma adiponectin. SAGE-Hindawi Access to Research 2011-01-18 /pmc/articles/PMC3034962/ /pubmed/21318144 http://dx.doi.org/10.4061/2011/194721 Text en Copyright © 2011 Chih-Hsun Chu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chu, Chih-Hsun
Lam, Hing-Chung
Lee, Jenn-Kuen
Lu, Chih-Chen
Sun, Chun-Chin
Wang, Mei-Chun
Chuang, Ming-Ju
Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels
title Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels
title_full Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels
title_fullStr Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels
title_full_unstemmed Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels
title_short Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels
title_sort hyperthyroidism-associated insulin resistance is not mediated by adiponectin levels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034962/
https://www.ncbi.nlm.nih.gov/pubmed/21318144
http://dx.doi.org/10.4061/2011/194721
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