AMP-Activated Protein Kinase Activation during Cardioplegia-Induced Hypoxia/Reoxygenation Injury Attenuates Cardiomyocytic Apoptosis via Reduction of Endoplasmic Reticulum Stress

Cardioplegic-induced H/R injury results in cardiomyocytic apoptosis. AMPK has been shown to reduce ER stress and the unfolded protein response (UPR). Whether AMPK activation can attenuate cardiomyocytic apoptosis after cardioplegia-induced H/R injury is unknown. Cardiomyocytes were exposed to simula...

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Detalles Bibliográficos
Autores principales: Yeh, Chi-Hsiao, Chen, Tzu-Ping, Wang, Yao-Chang, Lin, Yu-Min, Fang, Shu-Wen
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034973/
https://www.ncbi.nlm.nih.gov/pubmed/21318153
http://dx.doi.org/10.1155/2010/130636

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