The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring

Evaluating the number, phenotypic characteristics, and function of immunosuppressive cells in the tumor microenvironment and peripheral blood could elucidate the antitumor immune response and provide information to evaluate the efficacy of cancer vaccines. Further studies are needed to evaluate the...

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Detalles Bibliográficos
Autores principales: Vergati, Matteo, Schlom, Jeffrey, Tsang, Kwong Y.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034984/
https://www.ncbi.nlm.nih.gov/pubmed/21318157
http://dx.doi.org/10.1155/2011/182413
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author Vergati, Matteo
Schlom, Jeffrey
Tsang, Kwong Y.
author_facet Vergati, Matteo
Schlom, Jeffrey
Tsang, Kwong Y.
author_sort Vergati, Matteo
collection PubMed
description Evaluating the number, phenotypic characteristics, and function of immunosuppressive cells in the tumor microenvironment and peripheral blood could elucidate the antitumor immune response and provide information to evaluate the efficacy of cancer vaccines. Further studies are needed to evaluate the correlation between changes in immunosuppressive cells and clinical outcomes of patients in cancer vaccine clinical trials. This paper focuses on the role of T-regulatory cells, myeloid-derived suppressor cells, and tumor-associated macrophages in cancer and cancer immunotherapy and their role in immune monitoring.
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spelling pubmed-30349842011-02-11 The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring Vergati, Matteo Schlom, Jeffrey Tsang, Kwong Y. J Biomed Biotechnol Review Article Evaluating the number, phenotypic characteristics, and function of immunosuppressive cells in the tumor microenvironment and peripheral blood could elucidate the antitumor immune response and provide information to evaluate the efficacy of cancer vaccines. Further studies are needed to evaluate the correlation between changes in immunosuppressive cells and clinical outcomes of patients in cancer vaccine clinical trials. This paper focuses on the role of T-regulatory cells, myeloid-derived suppressor cells, and tumor-associated macrophages in cancer and cancer immunotherapy and their role in immune monitoring. Hindawi Publishing Corporation 2011 2011-01-20 /pmc/articles/PMC3034984/ /pubmed/21318157 http://dx.doi.org/10.1155/2011/182413 Text en Copyright © 2011 Matteo Vergati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vergati, Matteo
Schlom, Jeffrey
Tsang, Kwong Y.
The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring
title The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring
title_full The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring
title_fullStr The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring
title_full_unstemmed The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring
title_short The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring
title_sort consequence of immune suppressive cells in the use of therapeutic cancer vaccines and their importance in immune monitoring
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034984/
https://www.ncbi.nlm.nih.gov/pubmed/21318157
http://dx.doi.org/10.1155/2011/182413
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