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Different Influences on Tacrolimus Pharmacokinetics by Coadministrations of Zhi Ke and Zhi Shi in Rats

Tacrolimus, an immunosuppressant with narrow therapeutic window, has been used widely in transplant patients. Grapefruit juice and pomelo have been reported to increase the blood levels of tacrolimus. Zhi Ke and Zhi Shi, the ripe peels and unripe fruits of Citrus aurantium which is chemotaxonomicall...

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Detalles Bibliográficos
Autores principales:	Lin, Shiuan-Pey, Wu, Ping-Ping, Hou, Yu-Chi, Tsai, Shang-Yuan, Wang, Meng-Ju, Fang, Shih-Hua, Chao, Pei-Dawn Lee
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035000/ https://www.ncbi.nlm.nih.gov/pubmed/21318106 http://dx.doi.org/10.1155/2011/751671

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