Quantifying Protein Function Specificity in the Gene Ontology

Quantitative or numerical metrics of protein function specificity made possible by the Gene Ontology are useful in that they enable development of distance or similarity measures between protein functions. Here we describe how to calculate four measures of function specificity for GO terms: 1) numbe...

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Detalles Bibliográficos
Autores principales: Louie, Brenton, Bergen, Silas, Higdon, Roger, Kolker, Eugene
Formato: Texto
Lenguaje:English
Publicado: Michigan State University 2010
Materias:
Standard Operating Procedures
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035283/
https://www.ncbi.nlm.nih.gov/pubmed/21304708
http://dx.doi.org/10.4056/sigs.561626
Descripción
Sumario:Quantitative or numerical metrics of protein function specificity made possible by the Gene Ontology are useful in that they enable development of distance or similarity measures between protein functions. Here we describe how to calculate four measures of function specificity for GO terms: 1) number of ancestor terms; 2) number of offspring terms; 3) proportion of terms; and 4) Information Content (IC). We discuss the relationship between the metrics and the strengths and weaknesses of each.

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