Theoretical and empirical quality assessment of transcription factor-binding motifs

Position-specific scoring matrices (PSSMs) are routinely used to predict transcription factor (TF)-binding sites in genome sequences. However, their reliability to predict novel binding sites can be far from optimum, due to the use of a small number of training sites or the inappropriate choice of p...

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Detalles Bibliográficos
Autores principales: Medina-Rivera, Alejandra, Abreu-Goodger, Cei, Thomas-Chollier, Morgane, Salgado, Heladia, Collado-Vides, Julio, van Helden, Jacques
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035439/
https://www.ncbi.nlm.nih.gov/pubmed/20923783
http://dx.doi.org/10.1093/nar/gkq710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035439/
https://www.ncbi.nlm.nih.gov/pubmed/20923783
http://dx.doi.org/10.1093/nar/gkq710

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