The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I

Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events m...

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Detalles Bibliográficos
Autores principales: Gentry, Amanda C., Juul, Sissel, Veigaard, Christopher, Knudsen, Birgitta R., Osheroff, Neil
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035449/
https://www.ncbi.nlm.nih.gov/pubmed/20855291
http://dx.doi.org/10.1093/nar/gkq822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035449/
https://www.ncbi.nlm.nih.gov/pubmed/20855291
http://dx.doi.org/10.1093/nar/gkq822

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