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Functional regulation of FEN1 nuclease and its link to cancer

Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The multiple nuclease activities of FEN1 allow it to participate in numerous DNA metabolic pathways, including Okazaki fragment maturation, stall...

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Detalles Bibliográficos
Autores principales: Zheng, Li, Jia, Jia, Finger, L. David, Guo, Zhigang, Zer, Cindy, Shen, Binghui
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035468/
https://www.ncbi.nlm.nih.gov/pubmed/20929870
http://dx.doi.org/10.1093/nar/gkq884

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