Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (–)-epigallocatechin-3-gallate

Excessive production of Aβ (amyloid β-peptide) has been shown to play an important role in the pathogenesis of AD (Alzheimer's disease). Although not yet well understood, aggregation of Aβ is known to cause toxicity to neurons. Our recent study demonstrated the ability for oligomeric Aβ to stim...

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Detalles Bibliográficos
Autores principales: He, Yan, Cui, Jiankun, Lee, James C-M, Ding, Shinghua, Chalimoniuk, Malgorzata, Simonyi, Agnes, Sun, Albert Y, Gu, Zezong, Weisman∥, Gary A, Gibson Wood, W, Sun, Grace Y
Formato: Texto
Lenguaje:English
Publicado: American Society for Neurochemistry 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035478/
https://www.ncbi.nlm.nih.gov/pubmed/21434871
http://dx.doi.org/10.1042/AN20100025

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