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Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda

From August 2000 through January 2001, a large epidemic of Ebola hemorrhagic fever occurred in Uganda, with 425 cases and 224 deaths. Starting from three laboratory-confirmed cases, we traced the chains of transmission for three generations, until we reached the primary case-patients (i.e., persons...

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Autores principales: Francesconi, Paolo, Yoti, Zabulon, Declich, Silvia, Onek, Paul Awil, Fabiani, Massimo, Olango, Joseph, Andraghetti, Roberta, Rollin, Pierre E., Opira, Cyprian, Greco, Donato, Salmaso, Stefania
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035551/
https://www.ncbi.nlm.nih.gov/pubmed/14718087
http://dx.doi.org/10.3201/eid0911.030339
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author Francesconi, Paolo
Yoti, Zabulon
Declich, Silvia
Onek, Paul Awil
Fabiani, Massimo
Olango, Joseph
Andraghetti, Roberta
Rollin, Pierre E.
Opira, Cyprian
Greco, Donato
Salmaso, Stefania
author_facet Francesconi, Paolo
Yoti, Zabulon
Declich, Silvia
Onek, Paul Awil
Fabiani, Massimo
Olango, Joseph
Andraghetti, Roberta
Rollin, Pierre E.
Opira, Cyprian
Greco, Donato
Salmaso, Stefania
author_sort Francesconi, Paolo
collection PubMed
description From August 2000 through January 2001, a large epidemic of Ebola hemorrhagic fever occurred in Uganda, with 425 cases and 224 deaths. Starting from three laboratory-confirmed cases, we traced the chains of transmission for three generations, until we reached the primary case-patients (i.e., persons with an unidentified source of infection). We then prospectively identified the other contacts in whom the disease had developed. To identify the risk factors associated with transmission, we interviewed both healthy and ill contacts (or their proxies) who had been reported by the case-patients (or their proxies) and who met the criteria set for contact tracing during surveillance. The patterns of exposure of 24 case-patients and 65 healthy contacts were defined, and crude and adjusted prevalence proportion ratios (PPR) were estimated for different types of exposure. Contact with the patient’s body fluids (PPR = 4.61%, 95% confidence interval 1.73 to 12.29) was the strongest risk factor, although transmission through fomites also seems possible.
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spelling pubmed-30355512011-02-15 Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda Francesconi, Paolo Yoti, Zabulon Declich, Silvia Onek, Paul Awil Fabiani, Massimo Olango, Joseph Andraghetti, Roberta Rollin, Pierre E. Opira, Cyprian Greco, Donato Salmaso, Stefania Emerg Infect Dis Research From August 2000 through January 2001, a large epidemic of Ebola hemorrhagic fever occurred in Uganda, with 425 cases and 224 deaths. Starting from three laboratory-confirmed cases, we traced the chains of transmission for three generations, until we reached the primary case-patients (i.e., persons with an unidentified source of infection). We then prospectively identified the other contacts in whom the disease had developed. To identify the risk factors associated with transmission, we interviewed both healthy and ill contacts (or their proxies) who had been reported by the case-patients (or their proxies) and who met the criteria set for contact tracing during surveillance. The patterns of exposure of 24 case-patients and 65 healthy contacts were defined, and crude and adjusted prevalence proportion ratios (PPR) were estimated for different types of exposure. Contact with the patient’s body fluids (PPR = 4.61%, 95% confidence interval 1.73 to 12.29) was the strongest risk factor, although transmission through fomites also seems possible. Centers for Disease Control and Prevention 2003-11 /pmc/articles/PMC3035551/ /pubmed/14718087 http://dx.doi.org/10.3201/eid0911.030339 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Francesconi, Paolo
Yoti, Zabulon
Declich, Silvia
Onek, Paul Awil
Fabiani, Massimo
Olango, Joseph
Andraghetti, Roberta
Rollin, Pierre E.
Opira, Cyprian
Greco, Donato
Salmaso, Stefania
Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda
title Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda
title_full Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda
title_fullStr Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda
title_full_unstemmed Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda
title_short Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda
title_sort ebola hemorrhagic fever transmission and risk factors of contacts, uganda
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035551/
https://www.ncbi.nlm.nih.gov/pubmed/14718087
http://dx.doi.org/10.3201/eid0911.030339
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