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Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda
From August 2000 through January 2001, a large epidemic of Ebola hemorrhagic fever occurred in Uganda, with 425 cases and 224 deaths. Starting from three laboratory-confirmed cases, we traced the chains of transmission for three generations, until we reached the primary case-patients (i.e., persons...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035551/ https://www.ncbi.nlm.nih.gov/pubmed/14718087 http://dx.doi.org/10.3201/eid0911.030339 |
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author | Francesconi, Paolo Yoti, Zabulon Declich, Silvia Onek, Paul Awil Fabiani, Massimo Olango, Joseph Andraghetti, Roberta Rollin, Pierre E. Opira, Cyprian Greco, Donato Salmaso, Stefania |
author_facet | Francesconi, Paolo Yoti, Zabulon Declich, Silvia Onek, Paul Awil Fabiani, Massimo Olango, Joseph Andraghetti, Roberta Rollin, Pierre E. Opira, Cyprian Greco, Donato Salmaso, Stefania |
author_sort | Francesconi, Paolo |
collection | PubMed |
description | From August 2000 through January 2001, a large epidemic of Ebola hemorrhagic fever occurred in Uganda, with 425 cases and 224 deaths. Starting from three laboratory-confirmed cases, we traced the chains of transmission for three generations, until we reached the primary case-patients (i.e., persons with an unidentified source of infection). We then prospectively identified the other contacts in whom the disease had developed. To identify the risk factors associated with transmission, we interviewed both healthy and ill contacts (or their proxies) who had been reported by the case-patients (or their proxies) and who met the criteria set for contact tracing during surveillance. The patterns of exposure of 24 case-patients and 65 healthy contacts were defined, and crude and adjusted prevalence proportion ratios (PPR) were estimated for different types of exposure. Contact with the patient’s body fluids (PPR = 4.61%, 95% confidence interval 1.73 to 12.29) was the strongest risk factor, although transmission through fomites also seems possible. |
format | Text |
id | pubmed-3035551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-30355512011-02-15 Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda Francesconi, Paolo Yoti, Zabulon Declich, Silvia Onek, Paul Awil Fabiani, Massimo Olango, Joseph Andraghetti, Roberta Rollin, Pierre E. Opira, Cyprian Greco, Donato Salmaso, Stefania Emerg Infect Dis Research From August 2000 through January 2001, a large epidemic of Ebola hemorrhagic fever occurred in Uganda, with 425 cases and 224 deaths. Starting from three laboratory-confirmed cases, we traced the chains of transmission for three generations, until we reached the primary case-patients (i.e., persons with an unidentified source of infection). We then prospectively identified the other contacts in whom the disease had developed. To identify the risk factors associated with transmission, we interviewed both healthy and ill contacts (or their proxies) who had been reported by the case-patients (or their proxies) and who met the criteria set for contact tracing during surveillance. The patterns of exposure of 24 case-patients and 65 healthy contacts were defined, and crude and adjusted prevalence proportion ratios (PPR) were estimated for different types of exposure. Contact with the patient’s body fluids (PPR = 4.61%, 95% confidence interval 1.73 to 12.29) was the strongest risk factor, although transmission through fomites also seems possible. Centers for Disease Control and Prevention 2003-11 /pmc/articles/PMC3035551/ /pubmed/14718087 http://dx.doi.org/10.3201/eid0911.030339 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Francesconi, Paolo Yoti, Zabulon Declich, Silvia Onek, Paul Awil Fabiani, Massimo Olango, Joseph Andraghetti, Roberta Rollin, Pierre E. Opira, Cyprian Greco, Donato Salmaso, Stefania Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda |
title | Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda |
title_full | Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda |
title_fullStr | Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda |
title_full_unstemmed | Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda |
title_short | Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda |
title_sort | ebola hemorrhagic fever transmission and risk factors of contacts, uganda |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035551/ https://www.ncbi.nlm.nih.gov/pubmed/14718087 http://dx.doi.org/10.3201/eid0911.030339 |
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