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Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

Ligand activation of liver X receptors (LXRs) has been shown to impact both lipid metabolism and inflammation. One complicating factor in studies utilizing synthetic LXR agonists is the potential for pharmacologic and receptor-independent effects. Here, we describe an LXR gain-of-function system tha...

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Detalles Bibliográficos
Autores principales:	Hong, Cynthia, Walczak, Robert, Dhamko, Helena, Bradley, Michelle N., Marathe, Chaitra, Boyadjian, Rima, Salazar, Jon V., Tontonoz, Peter
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035689/ https://www.ncbi.nlm.nih.gov/pubmed/21187453 http://dx.doi.org/10.1194/jlr.M010686

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