Pathogenesis of HIV in the Central Nervous System

HIV can infect the brain and impair central nervous system (CNS) function. Combination antiretroviral therapy (cART) has not eradicated CNS complications. HIV-associated neurocognitive disorders (HAND) remain common despite cART, although attenuated in severity. This may result from a combination of...

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Autores principales: Valcour, Victor, Sithinamsuwan, Pasiri, Letendre, Scott, Ances, Beau
Formato: Texto
Lenguaje:English
Publicado: Current Science Inc. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035797/
https://www.ncbi.nlm.nih.gov/pubmed/21191673
http://dx.doi.org/10.1007/s11904-010-0070-4
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author Valcour, Victor
Sithinamsuwan, Pasiri
Letendre, Scott
Ances, Beau
author_facet Valcour, Victor
Sithinamsuwan, Pasiri
Letendre, Scott
Ances, Beau
author_sort Valcour, Victor
collection PubMed
description HIV can infect the brain and impair central nervous system (CNS) function. Combination antiretroviral therapy (cART) has not eradicated CNS complications. HIV-associated neurocognitive disorders (HAND) remain common despite cART, although attenuated in severity. This may result from a combination of factors including inadequate treatment of HIV reservoirs such as circulating monocytes and glia, decreased effectiveness of cART in CNS, concurrent illnesses, stimulant use, and factors associated with prescribed drugs, including antiretrovirals. This review highlights recent investigations of HIV-related CNS injury with emphasis on cART-era neuropathological mechanisms in the context of both US and international settings.
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spelling pubmed-30357972011-03-16 Pathogenesis of HIV in the Central Nervous System Valcour, Victor Sithinamsuwan, Pasiri Letendre, Scott Ances, Beau Curr HIV/AIDS Rep Article HIV can infect the brain and impair central nervous system (CNS) function. Combination antiretroviral therapy (cART) has not eradicated CNS complications. HIV-associated neurocognitive disorders (HAND) remain common despite cART, although attenuated in severity. This may result from a combination of factors including inadequate treatment of HIV reservoirs such as circulating monocytes and glia, decreased effectiveness of cART in CNS, concurrent illnesses, stimulant use, and factors associated with prescribed drugs, including antiretrovirals. This review highlights recent investigations of HIV-related CNS injury with emphasis on cART-era neuropathological mechanisms in the context of both US and international settings. Current Science Inc. 2010-12-31 2011 /pmc/articles/PMC3035797/ /pubmed/21191673 http://dx.doi.org/10.1007/s11904-010-0070-4 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Valcour, Victor
Sithinamsuwan, Pasiri
Letendre, Scott
Ances, Beau
Pathogenesis of HIV in the Central Nervous System
title Pathogenesis of HIV in the Central Nervous System
title_full Pathogenesis of HIV in the Central Nervous System
title_fullStr Pathogenesis of HIV in the Central Nervous System
title_full_unstemmed Pathogenesis of HIV in the Central Nervous System
title_short Pathogenesis of HIV in the Central Nervous System
title_sort pathogenesis of hiv in the central nervous system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035797/
https://www.ncbi.nlm.nih.gov/pubmed/21191673
http://dx.doi.org/10.1007/s11904-010-0070-4
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