The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function

Precursor T-cell acute lymphoblastic leukemia (T-ALL) remains an important challenge in pediatric oncology. Because of the particularly poor prognosis of relapses, it is vital to identify molecular risk factors allowing early and effective treatment stratification. Activating NOTCH1 mutations signif...

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Detalles Bibliográficos
Autores principales: Kox, C, Zimmermann, M, Stanulla, M, Leible, S, Schrappe, M, Ludwig, W-D, Koehler, R, Tolle, G, Bandapalli, O R, Breit, S, Muckenthaler, M U, Kulozik, A E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035973/
https://www.ncbi.nlm.nih.gov/pubmed/20944675
http://dx.doi.org/10.1038/leu.2010.203

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