Cargando…

The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population

The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups....

Descripción completa

Detalles Bibliográficos
Autores principales: Cimponeriu, Danut, Apostol, Pompilia, Radu, Irina, Craciun, Anne Marie, Serafinceanu, Cristian, Toma, Mihai, Panaite, Cristian, Cheta, Dan
Formato: Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036149/
https://www.ncbi.nlm.nih.gov/pubmed/21637566
http://dx.doi.org/10.1590/S1415-47572010005000074
_version_ 1782197860522000384
author Cimponeriu, Danut
Apostol, Pompilia
Radu, Irina
Craciun, Anne Marie
Serafinceanu, Cristian
Toma, Mihai
Panaite, Cristian
Cheta, Dan
author_facet Cimponeriu, Danut
Apostol, Pompilia
Radu, Irina
Craciun, Anne Marie
Serafinceanu, Cristian
Toma, Mihai
Panaite, Cristian
Cheta, Dan
author_sort Cimponeriu, Danut
collection PubMed
description The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified.
format Text
id pubmed-3036149
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Sociedade Brasileira de Genética
record_format MEDLINE/PubMed
spelling pubmed-30361492011-06-02 The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population Cimponeriu, Danut Apostol, Pompilia Radu, Irina Craciun, Anne Marie Serafinceanu, Cristian Toma, Mihai Panaite, Cristian Cheta, Dan Genet Mol Biol Human and Medical Genetics The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified. Sociedade Brasileira de Genética 2010 2010-12-01 /pmc/articles/PMC3036149/ /pubmed/21637566 http://dx.doi.org/10.1590/S1415-47572010005000074 Text en Copyright © 2010, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Human and Medical Genetics
Cimponeriu, Danut
Apostol, Pompilia
Radu, Irina
Craciun, Anne Marie
Serafinceanu, Cristian
Toma, Mihai
Panaite, Cristian
Cheta, Dan
The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
title The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
title_full The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
title_fullStr The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
title_full_unstemmed The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
title_short The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
title_sort insulin polymorphism -23hph increases the risk for type 1 diabetes mellitus in the romanian population
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036149/
https://www.ncbi.nlm.nih.gov/pubmed/21637566
http://dx.doi.org/10.1590/S1415-47572010005000074
work_keys_str_mv AT cimponeriudanut theinsulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT apostolpompilia theinsulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT raduirina theinsulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT craciunannemarie theinsulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT serafinceanucristian theinsulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT tomamihai theinsulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT panaitecristian theinsulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT chetadan theinsulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT cimponeriudanut insulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT apostolpompilia insulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT raduirina insulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT craciunannemarie insulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT serafinceanucristian insulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT tomamihai insulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT panaitecristian insulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation
AT chetadan insulinpolymorphism23hphincreasestheriskfortype1diabetesmellitusintheromanianpopulation