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The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups....
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Genética
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036149/ https://www.ncbi.nlm.nih.gov/pubmed/21637566 http://dx.doi.org/10.1590/S1415-47572010005000074 |
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author | Cimponeriu, Danut Apostol, Pompilia Radu, Irina Craciun, Anne Marie Serafinceanu, Cristian Toma, Mihai Panaite, Cristian Cheta, Dan |
author_facet | Cimponeriu, Danut Apostol, Pompilia Radu, Irina Craciun, Anne Marie Serafinceanu, Cristian Toma, Mihai Panaite, Cristian Cheta, Dan |
author_sort | Cimponeriu, Danut |
collection | PubMed |
description | The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified. |
format | Text |
id | pubmed-3036149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-30361492011-06-02 The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population Cimponeriu, Danut Apostol, Pompilia Radu, Irina Craciun, Anne Marie Serafinceanu, Cristian Toma, Mihai Panaite, Cristian Cheta, Dan Genet Mol Biol Human and Medical Genetics The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified. Sociedade Brasileira de Genética 2010 2010-12-01 /pmc/articles/PMC3036149/ /pubmed/21637566 http://dx.doi.org/10.1590/S1415-47572010005000074 Text en Copyright © 2010, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Human and Medical Genetics Cimponeriu, Danut Apostol, Pompilia Radu, Irina Craciun, Anne Marie Serafinceanu, Cristian Toma, Mihai Panaite, Cristian Cheta, Dan The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population |
title | The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population |
title_full | The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population |
title_fullStr | The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population |
title_full_unstemmed | The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population |
title_short | The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population |
title_sort | insulin polymorphism -23hph increases the risk for type 1 diabetes mellitus in the romanian population |
topic | Human and Medical Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036149/ https://www.ncbi.nlm.nih.gov/pubmed/21637566 http://dx.doi.org/10.1590/S1415-47572010005000074 |
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