Cargando…
Successful Targeting and Disruption of an Integrated Reporter Lentivirus Using the Engineered Homing Endonuclease Y2 I-AniI
Current antiviral therapy does not cure HIV-infected individuals because the virus establishes lifelong latent infection within long-lived memory T cells as integrated HIV proviral DNA. Here, we report a new therapeutic approach that aims to cure cells of latent HIV infection by rendering latent vir...
Autores principales: | Aubert, Martine, Ryu, Byoung Y., Banks, Lindsey, Rawlings, David J., Scharenberg, Andrew M., Jerome, Keith R. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036713/ https://www.ncbi.nlm.nih.gov/pubmed/21399673 http://dx.doi.org/10.1371/journal.pone.0016825 |
Ejemplares similares
-
In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease
por: Aubert, Martine, et al.
Publicado: (2014) -
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
por: Baxter, Sarah, et al.
Publicado: (2012) -
Homing endonuclease I-CreI derivatives with novel DNA target specificities
por: Rosen, Laura E., et al.
Publicado: (2006) -
Digital detection of endonuclease mediated gene disruption in the HIV provirus
por: Sedlak, Ruth Hall, et al.
Publicado: (2016) -
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
por: Wang, Yupeng, et al.
Publicado: (2014)