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Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis

BACKGROUND: Sterol biosynthesis is an essential pathway for fungal survival, and is the biochemical target of many antifungal agents. The antifungal drugs most widely used to treated fungal infections are compounds that inhibit cytochrome P450-dependent C14α-demethylase (CYP51), but other enzymes of...

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Detalles Bibliográficos
Autores principales:	Ishida, Kelly, Fernandes Rodrigues, Juliany Cola, Cammerer, Simon, Urbina, Julio A, Gilbert, Ian, de Souza, Wanderley, Rozental, Sonia
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036746/ https://www.ncbi.nlm.nih.gov/pubmed/21255433 http://dx.doi.org/10.1186/1476-0711-10-3

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