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Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is regulated by mitochondrial uncoupling protein-2 (UCP2), but opposing phenotypes, GSIS improvement and impairment, have been reported for different Ucp2-ablated mouse models. By measuring mitochondrial bioenergetics in attached INS-...

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Detalles Bibliográficos
Autores principales:	Affourtit, Charles, Jastroch, Martin, Brand, Martin D.
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier Science 2011
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036803/ https://www.ncbi.nlm.nih.gov/pubmed/21172424 http://dx.doi.org/10.1016/j.freeradbiomed.2010.12.020

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