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Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties
Recently, it was shown that proportional relationships exist between systolic, diastolic and mean pulmonary artery pressure (P (sys), P (dia) and P (mean)) and that they are maintained under various conditions in both health and disease. An arterial-ventricular interaction model was used to study th...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer US
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036810/ https://www.ncbi.nlm.nih.gov/pubmed/21423331 http://dx.doi.org/10.1007/s13239-010-0027-1 |
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author | Kind, Taco Faes, Theo J. C. Vonk-Noordegraaf, Anton Westerhof, Nico |
author_facet | Kind, Taco Faes, Theo J. C. Vonk-Noordegraaf, Anton Westerhof, Nico |
author_sort | Kind, Taco |
collection | PubMed |
description | Recently, it was shown that proportional relationships exist between systolic, diastolic and mean pulmonary artery pressure (P (sys), P (dia) and P (mean)) and that they are maintained under various conditions in both health and disease. An arterial-ventricular interaction model was used to study the contribution of model parameters to the ratios P (sys)/P (mean), and P (dia)/P (mean). The heart was modeled by a time-varying elastance function, and the arterial system by a three-element windkessel model consisting of peripheral resistance, R (p), arterial compliance C (a), and pulmonary artery characteristic impedance Z (0). Baseline model parameters were estimated in control subjects and compared to values estimated in patients with pulmonary hypertension. Results indicate that experimentally derived ratios P (sys)/P (mean) and P (dia)/P (mean) could be accurately reproduced using our model (1.59 and 0.61 vs. 1.55 and 0.64, respectively). Sensitivity analysis showed that the (empirical) constancy of P (sys)/P (mean) and P (dia)/P (mean) was primarily based on the inverse hyperbolic relation between total vascular resistance (R (T); calculated as R (p) + Z (0)) and C (a), (i.e. constant R (T) C (a) product). Of the cardiac parameters, only heart rate affected the pressure ratios, but the contribution was small. Therefore, we conclude that proportional relations between systolic, diastolic and mean pulmonary artery pressure result from the constancy of R (T) C (a) thus from pulmonary arterial properties, with only little influence of heart rate. |
format | Text |
id | pubmed-3036810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-30368102011-03-16 Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties Kind, Taco Faes, Theo J. C. Vonk-Noordegraaf, Anton Westerhof, Nico Cardiovasc Eng Technol Article Recently, it was shown that proportional relationships exist between systolic, diastolic and mean pulmonary artery pressure (P (sys), P (dia) and P (mean)) and that they are maintained under various conditions in both health and disease. An arterial-ventricular interaction model was used to study the contribution of model parameters to the ratios P (sys)/P (mean), and P (dia)/P (mean). The heart was modeled by a time-varying elastance function, and the arterial system by a three-element windkessel model consisting of peripheral resistance, R (p), arterial compliance C (a), and pulmonary artery characteristic impedance Z (0). Baseline model parameters were estimated in control subjects and compared to values estimated in patients with pulmonary hypertension. Results indicate that experimentally derived ratios P (sys)/P (mean) and P (dia)/P (mean) could be accurately reproduced using our model (1.59 and 0.61 vs. 1.55 and 0.64, respectively). Sensitivity analysis showed that the (empirical) constancy of P (sys)/P (mean) and P (dia)/P (mean) was primarily based on the inverse hyperbolic relation between total vascular resistance (R (T); calculated as R (p) + Z (0)) and C (a), (i.e. constant R (T) C (a) product). Of the cardiac parameters, only heart rate affected the pressure ratios, but the contribution was small. Therefore, we conclude that proportional relations between systolic, diastolic and mean pulmonary artery pressure result from the constancy of R (T) C (a) thus from pulmonary arterial properties, with only little influence of heart rate. Springer US 2010-11-11 2011 /pmc/articles/PMC3036810/ /pubmed/21423331 http://dx.doi.org/10.1007/s13239-010-0027-1 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Kind, Taco Faes, Theo J. C. Vonk-Noordegraaf, Anton Westerhof, Nico Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties |
title | Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties |
title_full | Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties |
title_fullStr | Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties |
title_full_unstemmed | Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties |
title_short | Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties |
title_sort | proportional relations between systolic, diastolic and mean pulmonary artery pressure are explained by vascular properties |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036810/ https://www.ncbi.nlm.nih.gov/pubmed/21423331 http://dx.doi.org/10.1007/s13239-010-0027-1 |
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