Cargando…

Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties

Recently, it was shown that proportional relationships exist between systolic, diastolic and mean pulmonary artery pressure (P (sys), P (dia) and P (mean)) and that they are maintained under various conditions in both health and disease. An arterial-ventricular interaction model was used to study th...

Descripción completa

Detalles Bibliográficos
Autores principales: Kind, Taco, Faes, Theo J. C., Vonk-Noordegraaf, Anton, Westerhof, Nico
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036810/
https://www.ncbi.nlm.nih.gov/pubmed/21423331
http://dx.doi.org/10.1007/s13239-010-0027-1
_version_ 1782197901575847936
author Kind, Taco
Faes, Theo J. C.
Vonk-Noordegraaf, Anton
Westerhof, Nico
author_facet Kind, Taco
Faes, Theo J. C.
Vonk-Noordegraaf, Anton
Westerhof, Nico
author_sort Kind, Taco
collection PubMed
description Recently, it was shown that proportional relationships exist between systolic, diastolic and mean pulmonary artery pressure (P (sys), P (dia) and P (mean)) and that they are maintained under various conditions in both health and disease. An arterial-ventricular interaction model was used to study the contribution of model parameters to the ratios P (sys)/P (mean), and P (dia)/P (mean). The heart was modeled by a time-varying elastance function, and the arterial system by a three-element windkessel model consisting of peripheral resistance, R (p), arterial compliance C (a), and pulmonary artery characteristic impedance Z (0). Baseline model parameters were estimated in control subjects and compared to values estimated in patients with pulmonary hypertension. Results indicate that experimentally derived ratios P (sys)/P (mean) and P (dia)/P (mean) could be accurately reproduced using our model (1.59 and 0.61 vs. 1.55 and 0.64, respectively). Sensitivity analysis showed that the (empirical) constancy of P (sys)/P (mean) and P (dia)/P (mean) was primarily based on the inverse hyperbolic relation between total vascular resistance (R (T); calculated as R (p) + Z (0)) and C (a), (i.e. constant R (T) C (a) product). Of the cardiac parameters, only heart rate affected the pressure ratios, but the contribution was small. Therefore, we conclude that proportional relations between systolic, diastolic and mean pulmonary artery pressure result from the constancy of R (T) C (a) thus from pulmonary arterial properties, with only little influence of heart rate.
format Text
id pubmed-3036810
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-30368102011-03-16 Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties Kind, Taco Faes, Theo J. C. Vonk-Noordegraaf, Anton Westerhof, Nico Cardiovasc Eng Technol Article Recently, it was shown that proportional relationships exist between systolic, diastolic and mean pulmonary artery pressure (P (sys), P (dia) and P (mean)) and that they are maintained under various conditions in both health and disease. An arterial-ventricular interaction model was used to study the contribution of model parameters to the ratios P (sys)/P (mean), and P (dia)/P (mean). The heart was modeled by a time-varying elastance function, and the arterial system by a three-element windkessel model consisting of peripheral resistance, R (p), arterial compliance C (a), and pulmonary artery characteristic impedance Z (0). Baseline model parameters were estimated in control subjects and compared to values estimated in patients with pulmonary hypertension. Results indicate that experimentally derived ratios P (sys)/P (mean) and P (dia)/P (mean) could be accurately reproduced using our model (1.59 and 0.61 vs. 1.55 and 0.64, respectively). Sensitivity analysis showed that the (empirical) constancy of P (sys)/P (mean) and P (dia)/P (mean) was primarily based on the inverse hyperbolic relation between total vascular resistance (R (T); calculated as R (p) + Z (0)) and C (a), (i.e. constant R (T) C (a) product). Of the cardiac parameters, only heart rate affected the pressure ratios, but the contribution was small. Therefore, we conclude that proportional relations between systolic, diastolic and mean pulmonary artery pressure result from the constancy of R (T) C (a) thus from pulmonary arterial properties, with only little influence of heart rate. Springer US 2010-11-11 2011 /pmc/articles/PMC3036810/ /pubmed/21423331 http://dx.doi.org/10.1007/s13239-010-0027-1 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Kind, Taco
Faes, Theo J. C.
Vonk-Noordegraaf, Anton
Westerhof, Nico
Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties
title Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties
title_full Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties
title_fullStr Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties
title_full_unstemmed Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties
title_short Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties
title_sort proportional relations between systolic, diastolic and mean pulmonary artery pressure are explained by vascular properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036810/
https://www.ncbi.nlm.nih.gov/pubmed/21423331
http://dx.doi.org/10.1007/s13239-010-0027-1
work_keys_str_mv AT kindtaco proportionalrelationsbetweensystolicdiastolicandmeanpulmonaryarterypressureareexplainedbyvascularproperties
AT faestheojc proportionalrelationsbetweensystolicdiastolicandmeanpulmonaryarterypressureareexplainedbyvascularproperties
AT vonknoordegraafanton proportionalrelationsbetweensystolicdiastolicandmeanpulmonaryarterypressureareexplainedbyvascularproperties
AT westerhofnico proportionalrelationsbetweensystolicdiastolicandmeanpulmonaryarterypressureareexplainedbyvascularproperties