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Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques
This review summarizes the chromosomal changes detected by molecular cytogenetic approaches in esophageal squamous cell carcinoma (ESCC), the ninth most common malignancy in the world. Whole genome analyses of ESCC cell lines and tumors indicated that the most frequent genomic gains occurred at 1, 2...
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Formato: | Texto |
Lenguaje: | English |
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Sociedade Brasileira de Genética
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036856/ https://www.ncbi.nlm.nih.gov/pubmed/21637470 http://dx.doi.org/10.1590/S1415-47572010005000028 |
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author | Bellini, Marilanda Ferreira Silva, Ana Elizabete Varella-Garcia, Marileila |
author_facet | Bellini, Marilanda Ferreira Silva, Ana Elizabete Varella-Garcia, Marileila |
author_sort | Bellini, Marilanda Ferreira |
collection | PubMed |
description | This review summarizes the chromosomal changes detected by molecular cytogenetic approaches in esophageal squamous cell carcinoma (ESCC), the ninth most common malignancy in the world. Whole genome analyses of ESCC cell lines and tumors indicated that the most frequent genomic gains occurred at 1, 2q, 3q, 5p, 6p, 7, 8q, 9q, 11q, 12p, 14q, 15q, 16, 17, 18p, 19q, 20q, 22q and X, with focal amplifications at 1q32, 2p16-22, 3q25-28, 5p13-15.3, 7p12-22, 7q21-22, 8q23-24.2, 9q34, 10q21, 11p11.2, 11q13, 13q32, 14q13-14, 14q21, 14q31-32, 15q22-26, 17p11.2, 18p11.2-11.3 and 20p11.2. Recurrent losses involved 3p, 4, 5q, 6q, 7q, 8p, 9, 10p, 12p, 13, 14p, 15p, 18, 19p, 20, 22, Xp and Y. Gains at 5p and 7q, and deletions at 4p, 9p, and 11q were significant prognostic factors for patients with ESCC. Gains at 6p and 20p, and losses at 10p and 10q were the most significant imbalances, both in primary carcinoma and in metastases, which suggested that these regions may harbor oncogenes and tumor suppressor genes. Gains at 12p and losses at 3p may be associated with poor relapse-free survival. The clinical applicability of these changes as markers for the diagnosis and prognosis of ESCC, or as molecular targets for personalized therapy should be evaluated. |
format | Text |
id | pubmed-3036856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-30368562011-06-02 Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques Bellini, Marilanda Ferreira Silva, Ana Elizabete Varella-Garcia, Marileila Genet Mol Biol Review Article This review summarizes the chromosomal changes detected by molecular cytogenetic approaches in esophageal squamous cell carcinoma (ESCC), the ninth most common malignancy in the world. Whole genome analyses of ESCC cell lines and tumors indicated that the most frequent genomic gains occurred at 1, 2q, 3q, 5p, 6p, 7, 8q, 9q, 11q, 12p, 14q, 15q, 16, 17, 18p, 19q, 20q, 22q and X, with focal amplifications at 1q32, 2p16-22, 3q25-28, 5p13-15.3, 7p12-22, 7q21-22, 8q23-24.2, 9q34, 10q21, 11p11.2, 11q13, 13q32, 14q13-14, 14q21, 14q31-32, 15q22-26, 17p11.2, 18p11.2-11.3 and 20p11.2. Recurrent losses involved 3p, 4, 5q, 6q, 7q, 8p, 9, 10p, 12p, 13, 14p, 15p, 18, 19p, 20, 22, Xp and Y. Gains at 5p and 7q, and deletions at 4p, 9p, and 11q were significant prognostic factors for patients with ESCC. Gains at 6p and 20p, and losses at 10p and 10q were the most significant imbalances, both in primary carcinoma and in metastases, which suggested that these regions may harbor oncogenes and tumor suppressor genes. Gains at 12p and losses at 3p may be associated with poor relapse-free survival. The clinical applicability of these changes as markers for the diagnosis and prognosis of ESCC, or as molecular targets for personalized therapy should be evaluated. Sociedade Brasileira de Genética 2010 2010-06-01 /pmc/articles/PMC3036856/ /pubmed/21637470 http://dx.doi.org/10.1590/S1415-47572010005000028 Text en Copyright © 2010, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bellini, Marilanda Ferreira Silva, Ana Elizabete Varella-Garcia, Marileila Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques |
title | Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques |
title_full | Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques |
title_fullStr | Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques |
title_full_unstemmed | Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques |
title_short | Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques |
title_sort | genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036856/ https://www.ncbi.nlm.nih.gov/pubmed/21637470 http://dx.doi.org/10.1590/S1415-47572010005000028 |
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