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RNAi-mediated silencing of the Bmi-1 gene causes growth inhibition and enhances doxorubicin-induced apoptosis in MCF-7 cells

The oncogene Bmi-1 is a member of the Polycomb group gene family. Its expression is found to be greatly increased in a number of malignant tumors including breast cancer. This could suggest Bmi-1 as a potent therapeutic target. In this study, RNAi was introduced to down-regulate the expression of Bm...

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Detalles Bibliográficos
Autores principales:	Wu, Xiang-mei, Liu, Xing, Bu, You-quan, Sengupta, Joyeeta, Cui, Hong-juan, Yi, Fa-ping, Liu, Tao, Yuan, Chen-fu, Shi, Yan-yan, Song, Fang-zhou
Formato:	Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Genética 2009
Materias:	Human and Medical Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036904/ https://www.ncbi.nlm.nih.gov/pubmed/21637439 http://dx.doi.org/10.1590/S1415-47572009005000092

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