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Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease
We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the gro...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Sociedade Brasileira de Genética
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036926/ https://www.ncbi.nlm.nih.gov/pubmed/21637677 http://dx.doi.org/10.1590/S1415-47572009005000035 |
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author | Zhong, Chen Quanzhong, Yin Genshan, Ma Hua, Zhang Ruolong, Zheng Jiahong, Wang Chunheng, Gao |
author_facet | Zhong, Chen Quanzhong, Yin Genshan, Ma Hua, Zhang Ruolong, Zheng Jiahong, Wang Chunheng, Gao |
author_sort | Zhong, Chen |
collection | PubMed |
description | We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD. |
format | Text |
id | pubmed-3036926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-30369262011-06-02 Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease Zhong, Chen Quanzhong, Yin Genshan, Ma Hua, Zhang Ruolong, Zheng Jiahong, Wang Chunheng, Gao Genet Mol Biol Human and Medical Genetics We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD. Sociedade Brasileira de Genética 2009 2009-06-01 /pmc/articles/PMC3036926/ /pubmed/21637677 http://dx.doi.org/10.1590/S1415-47572009005000035 Text en Copyright © 2009, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Human and Medical Genetics Zhong, Chen Quanzhong, Yin Genshan, Ma Hua, Zhang Ruolong, Zheng Jiahong, Wang Chunheng, Gao Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease |
title | Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease |
title_full | Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease |
title_fullStr | Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease |
title_full_unstemmed | Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease |
title_short | Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease |
title_sort | myeloperoxidase gene-463g > a polymorphism and premature coronary artery disease |
topic | Human and Medical Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036926/ https://www.ncbi.nlm.nih.gov/pubmed/21637677 http://dx.doi.org/10.1590/S1415-47572009005000035 |
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