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Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease

We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the gro...

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Autores principales: Zhong, Chen, Quanzhong, Yin, Genshan, Ma, Hua, Zhang, Ruolong, Zheng, Jiahong, Wang, Chunheng, Gao
Formato: Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036926/
https://www.ncbi.nlm.nih.gov/pubmed/21637677
http://dx.doi.org/10.1590/S1415-47572009005000035
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author Zhong, Chen
Quanzhong, Yin
Genshan, Ma
Hua, Zhang
Ruolong, Zheng
Jiahong, Wang
Chunheng, Gao
author_facet Zhong, Chen
Quanzhong, Yin
Genshan, Ma
Hua, Zhang
Ruolong, Zheng
Jiahong, Wang
Chunheng, Gao
author_sort Zhong, Chen
collection PubMed
description We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.
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spelling pubmed-30369262011-06-02 Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease Zhong, Chen Quanzhong, Yin Genshan, Ma Hua, Zhang Ruolong, Zheng Jiahong, Wang Chunheng, Gao Genet Mol Biol Human and Medical Genetics We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD. Sociedade Brasileira de Genética 2009 2009-06-01 /pmc/articles/PMC3036926/ /pubmed/21637677 http://dx.doi.org/10.1590/S1415-47572009005000035 Text en Copyright © 2009, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Human and Medical Genetics
Zhong, Chen
Quanzhong, Yin
Genshan, Ma
Hua, Zhang
Ruolong, Zheng
Jiahong, Wang
Chunheng, Gao
Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease
title Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease
title_full Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease
title_fullStr Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease
title_full_unstemmed Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease
title_short Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease
title_sort myeloperoxidase gene-463g > a polymorphism and premature coronary artery disease
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036926/
https://www.ncbi.nlm.nih.gov/pubmed/21637677
http://dx.doi.org/10.1590/S1415-47572009005000035
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