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Relationship between initial PSA density with future PSA kinetics and repeat biopsies in men with prostate cancer on active surveillance

The objective of our study is to examine the correlation between PSA density (PSAd) at the time of diagnosis with PSA velocity (PSAV), PSA doubling time and tumour progression, on repeat biopsy, in men with prostate cancer on active surveillance. Data from 102 patients with clinically localized pros...

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Autores principales: Kotb, A F, Tanguay, S, Luz, M A, Kassouf, W, Aprikian, A G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036981/
https://www.ncbi.nlm.nih.gov/pubmed/20938463
http://dx.doi.org/10.1038/pcan.2010.36
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author Kotb, A F
Tanguay, S
Luz, M A
Kassouf, W
Aprikian, A G
author_facet Kotb, A F
Tanguay, S
Luz, M A
Kassouf, W
Aprikian, A G
author_sort Kotb, A F
collection PubMed
description The objective of our study is to examine the correlation between PSA density (PSAd) at the time of diagnosis with PSA velocity (PSAV), PSA doubling time and tumour progression, on repeat biopsy, in men with prostate cancer on active surveillance. Data from 102 patients with clinically localized prostate cancer on active surveillance in the period between 1992 and 2007, who had the necessary parameters available, were collected. PSAd was calculated and correlated with PSAV, PSA doubling time (PSADT), Gleason score at diagnosis and local progression on repeated biopsies. PSAV was 0.64 and 1.31 ng ml(–1) per year (P=0.02), PSADT of 192 and 113 months (P=0.4) for PSAd below and above 0.15, respectively. The rate of detecting high Gleason score (⩾7) at diagnosis was 6 and 23% for PSAd below and above 0.15, respectively. A total of 101 patients underwent at least a second biopsy and the incidence of upgrading was 10 and 31% for PSAd below and above 0.15, respectively (P=0.001). Although low PSAd is an accepted measure for suggesting insignificant prostate cancer, our study expands its role to indicate that PSAd <0.15 may be an additional clinical parameter that may suggest indolent disease, as measured by future PSAV and repeat biopsy over time.
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spelling pubmed-30369812011-03-07 Relationship between initial PSA density with future PSA kinetics and repeat biopsies in men with prostate cancer on active surveillance Kotb, A F Tanguay, S Luz, M A Kassouf, W Aprikian, A G Prostate Cancer Prostatic Dis Original Article The objective of our study is to examine the correlation between PSA density (PSAd) at the time of diagnosis with PSA velocity (PSAV), PSA doubling time and tumour progression, on repeat biopsy, in men with prostate cancer on active surveillance. Data from 102 patients with clinically localized prostate cancer on active surveillance in the period between 1992 and 2007, who had the necessary parameters available, were collected. PSAd was calculated and correlated with PSAV, PSA doubling time (PSADT), Gleason score at diagnosis and local progression on repeated biopsies. PSAV was 0.64 and 1.31 ng ml(–1) per year (P=0.02), PSADT of 192 and 113 months (P=0.4) for PSAd below and above 0.15, respectively. The rate of detecting high Gleason score (⩾7) at diagnosis was 6 and 23% for PSAd below and above 0.15, respectively. A total of 101 patients underwent at least a second biopsy and the incidence of upgrading was 10 and 31% for PSAd below and above 0.15, respectively (P=0.001). Although low PSAd is an accepted measure for suggesting insignificant prostate cancer, our study expands its role to indicate that PSAd <0.15 may be an additional clinical parameter that may suggest indolent disease, as measured by future PSAV and repeat biopsy over time. Nature Publishing Group 2011-03 2010-10-12 /pmc/articles/PMC3036981/ /pubmed/20938463 http://dx.doi.org/10.1038/pcan.2010.36 Text en Copyright © 2011 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Kotb, A F
Tanguay, S
Luz, M A
Kassouf, W
Aprikian, A G
Relationship between initial PSA density with future PSA kinetics and repeat biopsies in men with prostate cancer on active surveillance
title Relationship between initial PSA density with future PSA kinetics and repeat biopsies in men with prostate cancer on active surveillance
title_full Relationship between initial PSA density with future PSA kinetics and repeat biopsies in men with prostate cancer on active surveillance
title_fullStr Relationship between initial PSA density with future PSA kinetics and repeat biopsies in men with prostate cancer on active surveillance
title_full_unstemmed Relationship between initial PSA density with future PSA kinetics and repeat biopsies in men with prostate cancer on active surveillance
title_short Relationship between initial PSA density with future PSA kinetics and repeat biopsies in men with prostate cancer on active surveillance
title_sort relationship between initial psa density with future psa kinetics and repeat biopsies in men with prostate cancer on active surveillance
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036981/
https://www.ncbi.nlm.nih.gov/pubmed/20938463
http://dx.doi.org/10.1038/pcan.2010.36
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