Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness

BACKGROUND: Resistance to the neuraminidase inhibitor oseltamivir can be conferred by a well-characterized mutation in the neuraminidase gene, H275Y. In human H1N1 viruses that circulated in the first years of the 21st century, this mutation carried a fitness cost and resistant viruses were rare. Du...

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Detalles Bibliográficos
Autores principales: Brookes, Daniel W., Miah, Shahajahan, Lackenby, Angie, Hartgroves, Lorian, Barclay, Wendy S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037153/
https://www.ncbi.nlm.nih.gov/pubmed/21172786
http://dx.doi.org/10.1093/jac/dkq486

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