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G(12/13) Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets
BACKGROUND: We have previously shown that ADP-induced TXA(2) generation requires signaling from αIIbβ3 integrin in platelets. Here we observed that, unlike ADP, protease-activated receptor (PAR)-mediated TXA(2) generation occurs independently of αIIbβ3. PAR agonists, but not ADP, activate G(12/13) s...
Autores principales: | Bhavaraju, Kamala, Lakhani, Parth R., Dorsam, Robert T., Jin, Jianguo, Hitchcock, Ian S., Sanjay, Archana, Kunapuli, Satya P. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037367/ https://www.ncbi.nlm.nih.gov/pubmed/21347357 http://dx.doi.org/10.1371/journal.pone.0016586 |
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