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Molecular biology of histidine decarboxylase and prostaglandin receptors

Histamine and prostaglandins (PGs) play a variety of physiological roles as autacoids, which function in the vicinity of their sources and maintain local homeostasis in the body. They stimulate target cells by acting on their specific receptors, which are coupled to trimeric G proteins. For the prec...

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Autores principales: ICHIKAWA, Atsushi, SUGIMOTO, Yukihiko, TANAKA, Satoshi
Formato: Texto
Lenguaje:English
Publicado: The Japan Academy 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037517/
https://www.ncbi.nlm.nih.gov/pubmed/20948178
http://dx.doi.org/10.2183/pjab.86.848
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author ICHIKAWA, Atsushi
SUGIMOTO, Yukihiko
TANAKA, Satoshi
author_facet ICHIKAWA, Atsushi
SUGIMOTO, Yukihiko
TANAKA, Satoshi
author_sort ICHIKAWA, Atsushi
collection PubMed
description Histamine and prostaglandins (PGs) play a variety of physiological roles as autacoids, which function in the vicinity of their sources and maintain local homeostasis in the body. They stimulate target cells by acting on their specific receptors, which are coupled to trimeric G proteins. For the precise understanding of the physiological roles of histamine and PGs, it is necessary to clarify the molecular mechanisms involved in their synthesis as well as their receptor-mediated responses. We cloned the cDNAs for mouse l-histidine decarboxylase (HDC) and 6 mouse prostanoid receptors (4 PGE(2) receptors, PGF receptor, and PGI receptor). We then characterized the expression patterns and functions of these genes. Furthermore, we established gene-targeted mouse strains for HDC and PG receptors to explore the novel pathophysiological roles of histamine and PGs. We have here summarized our research, which should contribute to progress in the molecular biology of HDC and PG receptors.
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spelling pubmed-30375172011-05-19 Molecular biology of histidine decarboxylase and prostaglandin receptors ICHIKAWA, Atsushi SUGIMOTO, Yukihiko TANAKA, Satoshi Proc Jpn Acad Ser B Phys Biol Sci Review Histamine and prostaglandins (PGs) play a variety of physiological roles as autacoids, which function in the vicinity of their sources and maintain local homeostasis in the body. They stimulate target cells by acting on their specific receptors, which are coupled to trimeric G proteins. For the precise understanding of the physiological roles of histamine and PGs, it is necessary to clarify the molecular mechanisms involved in their synthesis as well as their receptor-mediated responses. We cloned the cDNAs for mouse l-histidine decarboxylase (HDC) and 6 mouse prostanoid receptors (4 PGE(2) receptors, PGF receptor, and PGI receptor). We then characterized the expression patterns and functions of these genes. Furthermore, we established gene-targeted mouse strains for HDC and PG receptors to explore the novel pathophysiological roles of histamine and PGs. We have here summarized our research, which should contribute to progress in the molecular biology of HDC and PG receptors. The Japan Academy 2010-10-08 /pmc/articles/PMC3037517/ /pubmed/20948178 http://dx.doi.org/10.2183/pjab.86.848 Text en © 2010 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
ICHIKAWA, Atsushi
SUGIMOTO, Yukihiko
TANAKA, Satoshi
Molecular biology of histidine decarboxylase and prostaglandin receptors
title Molecular biology of histidine decarboxylase and prostaglandin receptors
title_full Molecular biology of histidine decarboxylase and prostaglandin receptors
title_fullStr Molecular biology of histidine decarboxylase and prostaglandin receptors
title_full_unstemmed Molecular biology of histidine decarboxylase and prostaglandin receptors
title_short Molecular biology of histidine decarboxylase and prostaglandin receptors
title_sort molecular biology of histidine decarboxylase and prostaglandin receptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037517/
https://www.ncbi.nlm.nih.gov/pubmed/20948178
http://dx.doi.org/10.2183/pjab.86.848
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