Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.

[Image: see text] A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam’s structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analy...

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Autores principales: Oh, Dong-Chan, Poulsen, Michael, Currie, Cameron R., Clardy, Jon
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037738/
https://www.ncbi.nlm.nih.gov/pubmed/21247188
http://dx.doi.org/10.1021/ol102991d
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author Oh, Dong-Chan
Poulsen, Michael
Currie, Cameron R.
Clardy, Jon
author_facet Oh, Dong-Chan
Poulsen, Michael
Currie, Cameron R.
Clardy, Jon
author_sort Oh, Dong-Chan
collection PubMed
description [Image: see text] A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam’s structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM).
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spelling pubmed-30377382011-02-11 Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp. Oh, Dong-Chan Poulsen, Michael Currie, Cameron R. Clardy, Jon Org Lett [Image: see text] A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam’s structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM). American Chemical Society 2011-01-19 2011-02-18 /pmc/articles/PMC3037738/ /pubmed/21247188 http://dx.doi.org/10.1021/ol102991d Text en Copyright © 2011 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Oh, Dong-Chan
Poulsen, Michael
Currie, Cameron R.
Clardy, Jon
Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
title Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
title_full Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
title_fullStr Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
title_full_unstemmed Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
title_short Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
title_sort sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated streptomyces sp.
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037738/
https://www.ncbi.nlm.nih.gov/pubmed/21247188
http://dx.doi.org/10.1021/ol102991d
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AT curriecameronr sceliphrolactamapolyenemacrocycliclactamfromawaspassociatedstreptomycessp
AT clardyjon sceliphrolactamapolyenemacrocycliclactamfromawaspassociatedstreptomycessp

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