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Altered Small-World Brain Networks in Temporal Lobe in Patients with Schizophrenia Performing an Auditory Oddball Task

The functional architecture of the human brain has been extensively described in terms of complex networks characterized by efficient small-world features. Recent functional magnetic resonance imaging (fMRI) studies have found altered small-world topological properties of brain functional networks i...

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Autores principales: Yu, Qingbao, Sui, Jing, Rachakonda, Srinivas, He, Hao, Pearlson, Godfrey, Calhoun, Vince D.
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037777/
https://www.ncbi.nlm.nih.gov/pubmed/21369355
http://dx.doi.org/10.3389/fnsys.2011.00007
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author Yu, Qingbao
Sui, Jing
Rachakonda, Srinivas
He, Hao
Pearlson, Godfrey
Calhoun, Vince D.
author_facet Yu, Qingbao
Sui, Jing
Rachakonda, Srinivas
He, Hao
Pearlson, Godfrey
Calhoun, Vince D.
author_sort Yu, Qingbao
collection PubMed
description The functional architecture of the human brain has been extensively described in terms of complex networks characterized by efficient small-world features. Recent functional magnetic resonance imaging (fMRI) studies have found altered small-world topological properties of brain functional networks in patients with schizophrenia (SZ) during the resting state. However, little is known about the small-world properties of brain networks in the context of a task. In this study, we investigated the topological properties of human brain functional networks derived from fMRI during an auditory oddball (AOD) task. Data were obtained from 20 healthy controls and 20 SZ; A left and a right task-related network which consisted of the top activated voxels in temporal lobe of each hemisphere were analyzed separately. All voxels were detected by group independent component analysis. Connectivity of the left and right task-related networks were estimated by partial correlation analysis and thresholded to construct a set of undirected graphs. The small-worldness values were decreased in both hemispheres in SZ. In addition, SZ showed longer shortest path length and lower global efficiency only in the left task-related networks. These results suggested small-world attributes are altered during the AOD task-related networks in SZ which provided further evidences for brain dysfunction of connectivity in SZ.
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spelling pubmed-30377772011-03-02 Altered Small-World Brain Networks in Temporal Lobe in Patients with Schizophrenia Performing an Auditory Oddball Task Yu, Qingbao Sui, Jing Rachakonda, Srinivas He, Hao Pearlson, Godfrey Calhoun, Vince D. Front Syst Neurosci Neuroscience The functional architecture of the human brain has been extensively described in terms of complex networks characterized by efficient small-world features. Recent functional magnetic resonance imaging (fMRI) studies have found altered small-world topological properties of brain functional networks in patients with schizophrenia (SZ) during the resting state. However, little is known about the small-world properties of brain networks in the context of a task. In this study, we investigated the topological properties of human brain functional networks derived from fMRI during an auditory oddball (AOD) task. Data were obtained from 20 healthy controls and 20 SZ; A left and a right task-related network which consisted of the top activated voxels in temporal lobe of each hemisphere were analyzed separately. All voxels were detected by group independent component analysis. Connectivity of the left and right task-related networks were estimated by partial correlation analysis and thresholded to construct a set of undirected graphs. The small-worldness values were decreased in both hemispheres in SZ. In addition, SZ showed longer shortest path length and lower global efficiency only in the left task-related networks. These results suggested small-world attributes are altered during the AOD task-related networks in SZ which provided further evidences for brain dysfunction of connectivity in SZ. Frontiers Research Foundation 2011-02-08 /pmc/articles/PMC3037777/ /pubmed/21369355 http://dx.doi.org/10.3389/fnsys.2011.00007 Text en Copyright © 2011 Yu, Sui, Rachakonda, He, Pearlson and Calhoun. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and Frontiers Media SA, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Yu, Qingbao
Sui, Jing
Rachakonda, Srinivas
He, Hao
Pearlson, Godfrey
Calhoun, Vince D.
Altered Small-World Brain Networks in Temporal Lobe in Patients with Schizophrenia Performing an Auditory Oddball Task
title Altered Small-World Brain Networks in Temporal Lobe in Patients with Schizophrenia Performing an Auditory Oddball Task
title_full Altered Small-World Brain Networks in Temporal Lobe in Patients with Schizophrenia Performing an Auditory Oddball Task
title_fullStr Altered Small-World Brain Networks in Temporal Lobe in Patients with Schizophrenia Performing an Auditory Oddball Task
title_full_unstemmed Altered Small-World Brain Networks in Temporal Lobe in Patients with Schizophrenia Performing an Auditory Oddball Task
title_short Altered Small-World Brain Networks in Temporal Lobe in Patients with Schizophrenia Performing an Auditory Oddball Task
title_sort altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037777/
https://www.ncbi.nlm.nih.gov/pubmed/21369355
http://dx.doi.org/10.3389/fnsys.2011.00007
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