Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor
The ubiquitylation of cell cycle regulatory proteins by the large multimeric anaphase promoting complex (APC/C) controls sister chromatid segregation and the exit from mitosis 1,2. Selection of APC/C targets is achieved through recognition of destruction motifs, predominantly the D-box 3 and KEN-box...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037847/ https://www.ncbi.nlm.nih.gov/pubmed/21107322 http://dx.doi.org/10.1038/nature09625 |