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Unusual Structures Are Present in DNA Fragments Containing Super-Long Huntingtin CAG Repeats

BACKGROUND: In the R6/2 mouse model of Huntington's disease (HD), expansion of the CAG trinucleotide repeat length beyond about 300 repeats induces a novel phenotype associated with a reduction in transcription of the transgene. METHODOLOGY/PRINCIPAL FINDINGS: We analysed the structure of polym...

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Detalles Bibliográficos
Autores principales:	Duzdevich, Daniel, Li, Jinliang, Whang, Jhoon, Takahashi, Hirohide, Takeyasu, Kunio, Dryden, David T. F., Morton, A. Jennifer, Edwardson, J. Michael
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037965/ https://www.ncbi.nlm.nih.gov/pubmed/21347256 http://dx.doi.org/10.1371/journal.pone.0017119

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