Cargando…

Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin

Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary tuberculosis and started on a s...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Jeong Moon, Kim, Hyung Hun, Park, Seun Ja, Park, Moo In, Moon, Won
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037994/
https://www.ncbi.nlm.nih.gov/pubmed/21326858
http://dx.doi.org/10.1159/000323753
_version_ 1782198048865124352
author Choi, Jeong Moon
Kim, Hyung Hun
Park, Seun Ja
Park, Moo In
Moon, Won
author_facet Choi, Jeong Moon
Kim, Hyung Hun
Park, Seun Ja
Park, Moo In
Moon, Won
author_sort Choi, Jeong Moon
collection PubMed
description Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary tuberculosis and started on a standard HERZ regimen (isoniazid, ethambutol, rifampicin, pyrazinamide). After 4 months of HERZ, he presented with frequent bloody, mucoid, jelly-like diarrhea and lower abdominal pain. Sigmoidoscopy revealed multiple whitish plaques with edematous mucosa that were compatible with PMC. Biopsies from these lesions showed ulcer-related necrotic and granulation tissue. We stopped antitubercular treatment and started the patient on oral metronidazole. His symptoms completely resolved within 2 weeks. Antitubercular treatment was restarted by replacing rifampicin with levofloxacin. The patient did not present with diarrhea or bloody stool throughout the rest of treatment.
format Text
id pubmed-3037994
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-30379942011-02-15 Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin Choi, Jeong Moon Kim, Hyung Hun Park, Seun Ja Park, Moo In Moon, Won Case Rep Gastroenterol Published: January 2011 Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary tuberculosis and started on a standard HERZ regimen (isoniazid, ethambutol, rifampicin, pyrazinamide). After 4 months of HERZ, he presented with frequent bloody, mucoid, jelly-like diarrhea and lower abdominal pain. Sigmoidoscopy revealed multiple whitish plaques with edematous mucosa that were compatible with PMC. Biopsies from these lesions showed ulcer-related necrotic and granulation tissue. We stopped antitubercular treatment and started the patient on oral metronidazole. His symptoms completely resolved within 2 weeks. Antitubercular treatment was restarted by replacing rifampicin with levofloxacin. The patient did not present with diarrhea or bloody stool throughout the rest of treatment. S. Karger AG 2011-01-14 /pmc/articles/PMC3037994/ /pubmed/21326858 http://dx.doi.org/10.1159/000323753 Text en Copyright © 2011 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: January 2011
Choi, Jeong Moon
Kim, Hyung Hun
Park, Seun Ja
Park, Moo In
Moon, Won
Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin
title Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin
title_full Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin
title_fullStr Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin
title_full_unstemmed Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin
title_short Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin
title_sort development of pseudomembranous colitis four months after initiation of rifampicin
topic Published: January 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037994/
https://www.ncbi.nlm.nih.gov/pubmed/21326858
http://dx.doi.org/10.1159/000323753
work_keys_str_mv AT choijeongmoon developmentofpseudomembranouscolitisfourmonthsafterinitiationofrifampicin
AT kimhyunghun developmentofpseudomembranouscolitisfourmonthsafterinitiationofrifampicin
AT parkseunja developmentofpseudomembranouscolitisfourmonthsafterinitiationofrifampicin
AT parkmooin developmentofpseudomembranouscolitisfourmonthsafterinitiationofrifampicin
AT moonwon developmentofpseudomembranouscolitisfourmonthsafterinitiationofrifampicin