Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity

Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological anal...

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Detalles Bibliográficos
Autores principales: Amano, Mutsuki, Nakayama, Masanori, Kaibuchi, Kozo
Formato: Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038199/
https://www.ncbi.nlm.nih.gov/pubmed/20803696
http://dx.doi.org/10.1002/cm.20472
Descripción
Sumario:Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma, and is therefore considered to be a potential therapeutic target. This review focuses on the structure, function, and modes of activation and action of Rho-kinase.

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