Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity

Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological anal...

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Detalles Bibliográficos
Autores principales: Amano, Mutsuki, Nakayama, Masanori, Kaibuchi, Kozo
Formato: Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038199/
https://www.ncbi.nlm.nih.gov/pubmed/20803696
http://dx.doi.org/10.1002/cm.20472
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author Amano, Mutsuki
Nakayama, Masanori
Kaibuchi, Kozo
author_facet Amano, Mutsuki
Nakayama, Masanori
Kaibuchi, Kozo
author_sort Amano, Mutsuki
collection PubMed
description Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma, and is therefore considered to be a potential therapeutic target. This review focuses on the structure, function, and modes of activation and action of Rho-kinase.
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spelling pubmed-30381992011-02-15 Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity Amano, Mutsuki Nakayama, Masanori Kaibuchi, Kozo Cytoskeleton (Hoboken) Review Article Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma, and is therefore considered to be a potential therapeutic target. This review focuses on the structure, function, and modes of activation and action of Rho-kinase. John Wiley & Sons, Inc. 2010-09 2010-08-10 /pmc/articles/PMC3038199/ /pubmed/20803696 http://dx.doi.org/10.1002/cm.20472 Text en Copyright © 2010 Wiley-Liss, Inc., A Wiley Company http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Review Article
Amano, Mutsuki
Nakayama, Masanori
Kaibuchi, Kozo
Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity
title Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity
title_full Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity
title_fullStr Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity
title_full_unstemmed Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity
title_short Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity
title_sort rho-kinase/rock: a key regulator of the cytoskeleton and cell polarity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038199/
https://www.ncbi.nlm.nih.gov/pubmed/20803696
http://dx.doi.org/10.1002/cm.20472
work_keys_str_mv AT amanomutsuki rhokinaserockakeyregulatorofthecytoskeletonandcellpolarity
AT nakayamamasanori rhokinaserockakeyregulatorofthecytoskeletonandcellpolarity
AT kaibuchikozo rhokinaserockakeyregulatorofthecytoskeletonandcellpolarity

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