Conformational Dynamics of Actin: Effectors and Implications for Biological Function

Actin is a protein abundant in many cell types. Decades of investigations have provided evidence that it has many functions in living cells. The diverse morphology and dynamics of actin structures adapted to versatile cellular functions is established by a large repertoire of actin-binding proteins....

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Detalles Bibliográficos
Autores principales: Hild, Gábor, Bugyi, Beáta, Nyitrai, Miklós
Formato: Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038201/
https://www.ncbi.nlm.nih.gov/pubmed/20672362
http://dx.doi.org/10.1002/cm.20473
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author Hild, Gábor
Bugyi, Beáta
Nyitrai, Miklós
author_facet Hild, Gábor
Bugyi, Beáta
Nyitrai, Miklós
author_sort Hild, Gábor
collection PubMed
description Actin is a protein abundant in many cell types. Decades of investigations have provided evidence that it has many functions in living cells. The diverse morphology and dynamics of actin structures adapted to versatile cellular functions is established by a large repertoire of actin-binding proteins. The proper interactions with these proteins assume effective molecular adaptations from actin, in which its conformational transitions play essential role. This review attempts to summarise our current knowledge regarding the coupling between the conformational states of actin and its biological function.
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spelling pubmed-30382012011-02-15 Conformational Dynamics of Actin: Effectors and Implications for Biological Function Hild, Gábor Bugyi, Beáta Nyitrai, Miklós Cytoskeleton (Hoboken) Review Article Actin is a protein abundant in many cell types. Decades of investigations have provided evidence that it has many functions in living cells. The diverse morphology and dynamics of actin structures adapted to versatile cellular functions is established by a large repertoire of actin-binding proteins. The proper interactions with these proteins assume effective molecular adaptations from actin, in which its conformational transitions play essential role. This review attempts to summarise our current knowledge regarding the coupling between the conformational states of actin and its biological function. John Wiley & Sons, Inc. 2010-10 2010-07-29 /pmc/articles/PMC3038201/ /pubmed/20672362 http://dx.doi.org/10.1002/cm.20473 Text en Copyright © 2010 Wiley-Liss, Inc., A Wiley Company http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Review Article
Hild, Gábor
Bugyi, Beáta
Nyitrai, Miklós
Conformational Dynamics of Actin: Effectors and Implications for Biological Function
title Conformational Dynamics of Actin: Effectors and Implications for Biological Function
title_full Conformational Dynamics of Actin: Effectors and Implications for Biological Function
title_fullStr Conformational Dynamics of Actin: Effectors and Implications for Biological Function
title_full_unstemmed Conformational Dynamics of Actin: Effectors and Implications for Biological Function
title_short Conformational Dynamics of Actin: Effectors and Implications for Biological Function
title_sort conformational dynamics of actin: effectors and implications for biological function
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038201/
https://www.ncbi.nlm.nih.gov/pubmed/20672362
http://dx.doi.org/10.1002/cm.20473
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AT nyitraimiklos conformationaldynamicsofactineffectorsandimplicationsforbiologicalfunction

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