Estimation of Paracetamol and Aceclofenac in Tablet Formulation by Ratio Spectra Derivative Spectroscopy

A new sensitive, simple, rapid and precise method for simultaneous estimation of paracetamol and aceclofenac in combined tablet dosage form has been developed. The method is based on ratio derivative spectrophotometry. The amplitude in first derivative of the ratio spectra at 256 nm and 268 nm (mini...

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Detalles Bibliográficos
Autores principales: Nikam, A. D., Pawar, Sampada S., Gandhi, S. V.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038289/
https://www.ncbi.nlm.nih.gov/pubmed/21394261
http://dx.doi.org/10.4103/0250-474X.45403
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author Nikam, A. D.
Pawar, Sampada S.
Gandhi, S. V.
author_facet Nikam, A. D.
Pawar, Sampada S.
Gandhi, S. V.
author_sort Nikam, A. D.
collection PubMed
description A new sensitive, simple, rapid and precise method for simultaneous estimation of paracetamol and aceclofenac in combined tablet dosage form has been developed. The method is based on ratio derivative spectrophotometry. The amplitude in first derivative of the ratio spectra at 256 nm and 268 nm (minima) were selected to determine paracetamol and aceclofenac in combined formulation. The method showed good linearity, accuracy and reproducibility. Results of analysis were validated statistically and by recovery studies.
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spelling pubmed-30382892011-03-10 Estimation of Paracetamol and Aceclofenac in Tablet Formulation by Ratio Spectra Derivative Spectroscopy Nikam, A. D. Pawar, Sampada S. Gandhi, S. V. Indian J Pharm Sci Short Communication A new sensitive, simple, rapid and precise method for simultaneous estimation of paracetamol and aceclofenac in combined tablet dosage form has been developed. The method is based on ratio derivative spectrophotometry. The amplitude in first derivative of the ratio spectra at 256 nm and 268 nm (minima) were selected to determine paracetamol and aceclofenac in combined formulation. The method showed good linearity, accuracy and reproducibility. Results of analysis were validated statistically and by recovery studies. Medknow Publications 2008 /pmc/articles/PMC3038289/ /pubmed/21394261 http://dx.doi.org/10.4103/0250-474X.45403 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Nikam, A. D.
Pawar, Sampada S.
Gandhi, S. V.
Estimation of Paracetamol and Aceclofenac in Tablet Formulation by Ratio Spectra Derivative Spectroscopy
title Estimation of Paracetamol and Aceclofenac in Tablet Formulation by Ratio Spectra Derivative Spectroscopy
title_full Estimation of Paracetamol and Aceclofenac in Tablet Formulation by Ratio Spectra Derivative Spectroscopy
title_fullStr Estimation of Paracetamol and Aceclofenac in Tablet Formulation by Ratio Spectra Derivative Spectroscopy
title_full_unstemmed Estimation of Paracetamol and Aceclofenac in Tablet Formulation by Ratio Spectra Derivative Spectroscopy
title_short Estimation of Paracetamol and Aceclofenac in Tablet Formulation by Ratio Spectra Derivative Spectroscopy
title_sort estimation of paracetamol and aceclofenac in tablet formulation by ratio spectra derivative spectroscopy
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038289/
https://www.ncbi.nlm.nih.gov/pubmed/21394261
http://dx.doi.org/10.4103/0250-474X.45403
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AT gandhisv estimationofparacetamolandaceclofenacintabletformulationbyratiospectraderivativespectroscopy

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