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Treatment of Advanced Parkinson's Disease
Patients at late stage Parkinson's disease (PD) develop several motor and nonmotor complications, which dramatically impair their quality of life. These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucin...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038575/ https://www.ncbi.nlm.nih.gov/pubmed/21331376 http://dx.doi.org/10.4061/2010/480260 |
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author | Varanese, Sara Birnbaum, Zoe Rossi, Roger Di Rocco, Alessandro |
author_facet | Varanese, Sara Birnbaum, Zoe Rossi, Roger Di Rocco, Alessandro |
author_sort | Varanese, Sara |
collection | PubMed |
description | Patients at late stage Parkinson's disease (PD) develop several motor and nonmotor complications, which dramatically impair their quality of life. These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucinations, sleep disorders, depression, and psychosis. The therapeutic management should be driven by the attempt to create a balance between benefit and side effects of the pharmacological treatments available. Supportive care, including physical and rehabilitative interventions, speech therapy, occupational therapy, and nursing care, has a key role in the late stage of disease. In this review we discuss the several complications experienced by advance PD patients and their management. The importance of an integrative approach, including both pharmacological and supportive interventions, is emphasized. |
format | Text |
id | pubmed-3038575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-30385752011-02-17 Treatment of Advanced Parkinson's Disease Varanese, Sara Birnbaum, Zoe Rossi, Roger Di Rocco, Alessandro Parkinsons Dis Review Article Patients at late stage Parkinson's disease (PD) develop several motor and nonmotor complications, which dramatically impair their quality of life. These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucinations, sleep disorders, depression, and psychosis. The therapeutic management should be driven by the attempt to create a balance between benefit and side effects of the pharmacological treatments available. Supportive care, including physical and rehabilitative interventions, speech therapy, occupational therapy, and nursing care, has a key role in the late stage of disease. In this review we discuss the several complications experienced by advance PD patients and their management. The importance of an integrative approach, including both pharmacological and supportive interventions, is emphasized. SAGE-Hindawi Access to Research 2011-02-07 /pmc/articles/PMC3038575/ /pubmed/21331376 http://dx.doi.org/10.4061/2010/480260 Text en Copyright © 2010 Sara Varanese et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Varanese, Sara Birnbaum, Zoe Rossi, Roger Di Rocco, Alessandro Treatment of Advanced Parkinson's Disease |
title | Treatment of Advanced Parkinson's Disease |
title_full | Treatment of Advanced Parkinson's Disease |
title_fullStr | Treatment of Advanced Parkinson's Disease |
title_full_unstemmed | Treatment of Advanced Parkinson's Disease |
title_short | Treatment of Advanced Parkinson's Disease |
title_sort | treatment of advanced parkinson's disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038575/ https://www.ncbi.nlm.nih.gov/pubmed/21331376 http://dx.doi.org/10.4061/2010/480260 |
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