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TLRs, Alcohol, HCV, and Tumorigenesis
Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD). The Toll-like receptor (TL...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038599/ https://www.ncbi.nlm.nih.gov/pubmed/21331379 http://dx.doi.org/10.1155/2010/518674 |
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author | Machida, Keigo |
author_facet | Machida, Keigo |
author_sort | Machida, Keigo |
collection | PubMed |
description | Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD). The Toll-like receptor (TLR) signaling pathway is upregulated in chronic liver diseases. Alcoholism is associated with endotoxemia that stimulates expression of proinflammatory cytokine expression and inflammation in the liver and fat tissues. Recent studies of HCC have centered on cancer-initiating stem cell (CSC), including detection of CSC in cancer, identification of CSC markers, and isolation of CSC from human HCC cell lines. Synergism between alcohol and HCV may lead to liver tumorigenesis through TLR signaling. |
format | Text |
id | pubmed-3038599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30385992011-02-17 TLRs, Alcohol, HCV, and Tumorigenesis Machida, Keigo Gastroenterol Res Pract Review Article Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD). The Toll-like receptor (TLR) signaling pathway is upregulated in chronic liver diseases. Alcoholism is associated with endotoxemia that stimulates expression of proinflammatory cytokine expression and inflammation in the liver and fat tissues. Recent studies of HCC have centered on cancer-initiating stem cell (CSC), including detection of CSC in cancer, identification of CSC markers, and isolation of CSC from human HCC cell lines. Synergism between alcohol and HCV may lead to liver tumorigenesis through TLR signaling. Hindawi Publishing Corporation 2010 2011-02-09 /pmc/articles/PMC3038599/ /pubmed/21331379 http://dx.doi.org/10.1155/2010/518674 Text en Copyright © 2010 Keigo Machida. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Machida, Keigo TLRs, Alcohol, HCV, and Tumorigenesis |
title | TLRs, Alcohol, HCV, and Tumorigenesis |
title_full | TLRs, Alcohol, HCV, and Tumorigenesis |
title_fullStr | TLRs, Alcohol, HCV, and Tumorigenesis |
title_full_unstemmed | TLRs, Alcohol, HCV, and Tumorigenesis |
title_short | TLRs, Alcohol, HCV, and Tumorigenesis |
title_sort | tlrs, alcohol, hcv, and tumorigenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038599/ https://www.ncbi.nlm.nih.gov/pubmed/21331379 http://dx.doi.org/10.1155/2010/518674 |
work_keys_str_mv | AT machidakeigo tlrsalcoholhcvandtumorigenesis |