Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory

We used Drosophila olfactory memory in order to understand in vivo the molecular basis of cognitive defect in Fragile X syndrome. We observed that Fragile X protein (FMRP) was required acutely and interacted with argonaute1 and staufen in long-term memory (LTM). Occlusion of long-term memory formati...

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Autores principales: Bolduc, François V., Bell, Kimberly, Cox, Hilary, Broadie, Kendal, Tully, Tim
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038669/
https://www.ncbi.nlm.nih.gov/pubmed/18776892
http://dx.doi.org/10.1038/nn.2175
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author Bolduc, François V.
Bell, Kimberly
Cox, Hilary
Broadie, Kendal
Tully, Tim
author_facet Bolduc, François V.
Bell, Kimberly
Cox, Hilary
Broadie, Kendal
Tully, Tim
author_sort Bolduc, François V.
collection PubMed
description We used Drosophila olfactory memory in order to understand in vivo the molecular basis of cognitive defect in Fragile X syndrome. We observed that Fragile X protein (FMRP) was required acutely and interacted with argonaute1 and staufen in long-term memory (LTM). Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could impact negatively on cognition.
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spelling pubmed-30386692011-02-14 Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory Bolduc, François V. Bell, Kimberly Cox, Hilary Broadie, Kendal Tully, Tim Nat Neurosci Article We used Drosophila olfactory memory in order to understand in vivo the molecular basis of cognitive defect in Fragile X syndrome. We observed that Fragile X protein (FMRP) was required acutely and interacted with argonaute1 and staufen in long-term memory (LTM). Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could impact negatively on cognition. 2008-09-07 2008-10 /pmc/articles/PMC3038669/ /pubmed/18776892 http://dx.doi.org/10.1038/nn.2175 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Bolduc, François V.
Bell, Kimberly
Cox, Hilary
Broadie, Kendal
Tully, Tim
Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory
title Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory
title_full Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory
title_fullStr Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory
title_full_unstemmed Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory
title_short Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory
title_sort excess protein synthesis in drosophila fragile x mutants impairs long-term memory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038669/
https://www.ncbi.nlm.nih.gov/pubmed/18776892
http://dx.doi.org/10.1038/nn.2175
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