Genetically Engineered Alginate Lyase-PEG Conjugates Exhibit Enhanced Catalytic Function and Reduced Immunoreactivity

Alginate lyase enzymes represent prospective biotherapeutic agents for treating bacterial infections, particularly in the cystic fibrosis airway. To effectively deimmunize one therapeutic candidate while maintaining high level catalytic proficiency, a combined genetic engineering-PEGylation strategy...

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Detalles Bibliográficos
Autores principales: Lamppa, John W., Ackerman, Margaret E., Lai, Jennifer I., Scanlon, Thomas C., Griswold, Karl E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038863/
https://www.ncbi.nlm.nih.gov/pubmed/21340021
http://dx.doi.org/10.1371/journal.pone.0017042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038863/
https://www.ncbi.nlm.nih.gov/pubmed/21340021
http://dx.doi.org/10.1371/journal.pone.0017042

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