Advances in understanding ischemic acute kidney injury

Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understa...

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Detalles Bibliográficos
Autores principales: Munshi, Raj, Hsu, Christine, Himmelfarb, Jonathan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038966/
https://www.ncbi.nlm.nih.gov/pubmed/21288330
http://dx.doi.org/10.1186/1741-7015-9-11
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author Munshi, Raj
Hsu, Christine
Himmelfarb, Jonathan
author_facet Munshi, Raj
Hsu, Christine
Himmelfarb, Jonathan
author_sort Munshi, Raj
collection PubMed
description Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic AKI pathophysiology, the emerging relationship between ischemic AKI and development of progressive chronic kidney disease, and promising novel therapies currently under investigation. On the basis of recent breakthroughs in understanding the pathophysiology of ischemic AKI, therapies that can treat or even prevent ischemic AKI may become a reality in the near future.
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spelling pubmed-30389662011-02-15 Advances in understanding ischemic acute kidney injury Munshi, Raj Hsu, Christine Himmelfarb, Jonathan BMC Med Minireview Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic AKI pathophysiology, the emerging relationship between ischemic AKI and development of progressive chronic kidney disease, and promising novel therapies currently under investigation. On the basis of recent breakthroughs in understanding the pathophysiology of ischemic AKI, therapies that can treat or even prevent ischemic AKI may become a reality in the near future. BioMed Central 2011-02-02 /pmc/articles/PMC3038966/ /pubmed/21288330 http://dx.doi.org/10.1186/1741-7015-9-11 Text en Copyright ©2011 Munshi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Minireview
Munshi, Raj
Hsu, Christine
Himmelfarb, Jonathan
Advances in understanding ischemic acute kidney injury
title Advances in understanding ischemic acute kidney injury
title_full Advances in understanding ischemic acute kidney injury
title_fullStr Advances in understanding ischemic acute kidney injury
title_full_unstemmed Advances in understanding ischemic acute kidney injury
title_short Advances in understanding ischemic acute kidney injury
title_sort advances in understanding ischemic acute kidney injury
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038966/
https://www.ncbi.nlm.nih.gov/pubmed/21288330
http://dx.doi.org/10.1186/1741-7015-9-11
work_keys_str_mv AT munshiraj advancesinunderstandingischemicacutekidneyinjury
AT hsuchristine advancesinunderstandingischemicacutekidneyinjury
AT himmelfarbjonathan advancesinunderstandingischemicacutekidneyinjury

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