Cargando…

Syk-dependent Phosphorylation of CLEC-2: A NOVEL MECHANISM OF HEM-IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF SIGNALING

The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). In this study, we show that phosphorylation of CLEC-2 by the snake toxin rhodocytin is abolished in the absence of the tyr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Séverin, Sonia, Pollitt, Alice Y., Navarro-Nuñez, Leyre, Nash, Craig A., Mourão-Sá, Diego, Eble, Johannes A., Senis, Yotis A., Watson, Steve P.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039337/ https://www.ncbi.nlm.nih.gov/pubmed/21098033 http://dx.doi.org/10.1074/jbc.M110.167502

Ejemplares similares

Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)
por: Hughes, Craig E., et al.
Publicado: (2013)

Syk and Src Family Kinases Regulate C-type Lectin Receptor 2 (CLEC-2)-mediated Clustering of Podoplanin and Platelet Adhesion to Lymphatic Endothelial Cells
por: Pollitt, Alice Y., et al.
Publicado: (2014)

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2
por: Mori, Jun, et al.
Publicado: (2008)

Platelet Adhesion to Podoplanin Under Flow is Mediated by the Receptor CLEC-2 and Stabilised by Src/Syk-Dependent Platelet Signalling
por: Navarro-Núñez, Leyre, et al.
Publicado: (2015)

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
por: Thaker, Youg R., et al.
Publicado: (2017)

The Chlamydia Effector TarP Mimics the Mammalian Leucine-Aspartic Acid Motif of Paxillin to Subvert the Focal Adhesion Kinase during Invasion
por: Thwaites, Tristan, et al.
Publicado: (2014)

MMP activation–associated aminopeptidase N reveals a bivalent 14-3-3 binding motif
por: Kiehstaller, Sebastian, et al.
Publicado: (2021)

Skeletal Muscle Protein Tyrosine Phosphatase 1B Regulates Insulin Sensitivity in African Americans
por: Stull, April J., et al.
Publicado: (2012)

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis
por: Fukushima, Atsushi, et al.
Publicado: (2010)

Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo
por: Maile, Laura A., et al.
Publicado: (2008)

Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
por: Oriente, Francesco, et al.
Publicado: (2011)

Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)
por: Keshwani, Malik M., et al.
Publicado: (2011)

SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation
por: Liu, Hebin, et al.
Publicado: (2013)

Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways
por: Dickinson, Robin J., et al.
Publicado: (2011)

Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade: CONCOMITANT ACTIVATION OF RECEPTOR TYROSINE KINASES AND OF LRP-1 LEADS TO SUSTAINED ERK PHOSPHORYLATION VIA DOWN-REGULATION OF DUAL SPECIFICITY PHOSPHATASES (DUSP1 AND -6)
por: Geetha, Nishamol, et al.
Publicado: (2011)

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca(2+) Ions in Pancreatic β-Cells
por: Noordeen, Nafeesa A., et al.
Publicado: (2012)

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors
por: Weston, Cathryn, et al.
Publicado: (2016)

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin
por: Rondas, Dieter, et al.
Publicado: (2011)

The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β
por: Craft, Clarissa S., et al.
Publicado: (2014)

Identification of Human P2X1 Receptor-interacting Proteins Reveals a Role of the Cytoskeleton in Receptor Regulation
por: Lalo, Ulyana, et al.
Publicado: (2011)

Class II Histone Deacetylases Downregulate GLUT4 Transcription in Response to Increased cAMP Signaling in Cultured Adipocytes and Fasting Mice
por: Weems, Juston C., et al.
Publicado: (2012)

Elevated Carbon Dioxide Blunts Mammalian cAMP Signaling Dependent on Inositol 1,4,5-Triphosphate Receptor-mediated Ca(2+) Release
por: Cook, Zara C., et al.
Publicado: (2012)

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties
por: Watkins, Harriet A., et al.
Publicado: (2016)

Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice
por: Ropelle, Eduardo R., et al.
Publicado: (2013)

Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress
por: Senokuchi, Takafumi, et al.
Publicado: (2008)

Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
por: Soares, Marc A., et al.
Publicado: (2016)

Examining Crosstalk among Transforming Growth Factor β, Bone Morphogenetic Protein, and Wnt Pathways
por: Coster, Adam D., et al.
Publicado: (2017)

Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding
por: Telezhkin, Vsevolod, et al.
Publicado: (2012)

Temporal Profiling of Orexin Receptor-Arrestin-Ubiquitin Complexes Reveals Differences between Receptor Subtypes
por: Dalrymple, Matthew B., et al.
Publicado: (2011)

Nuclear Receptors HNF4α and LRH-1 Cooperate in Regulating Cyp7a1 in Vivo
por: Kir, Serkan, et al.
Publicado: (2012)

A ubiquitin-like domain controls protein kinase D dimerization and activation by trans-autophosphorylation
por: Elsner, Daniel J., et al.
Publicado: (2019)

Hyperglycemia Enhances IGF-I–Stimulated Src Activation via Increasing Nox4-Derived Reactive Oxygen Species in a PKCζ-Dependent Manner in Vascular Smooth Muscle Cells
por: Xi, Gang, et al.
Publicado: (2012)

Heat Shock Protein 90 Inhibitors Reduce Trafficking of ATP-gated P2X1 Receptors and Human Platelet Responsiveness
por: Lalo, Ulyana, et al.
Publicado: (2012)

Targeting Toll-like Receptor (TLR) Signaling by Toll/Interleukin-1 Receptor (TIR) Domain-containing Adapter Protein/MyD88 Adapter-like (TIRAP/Mal)-derived Decoy Peptides
por: Couture, Leah A., et al.
Publicado: (2012)

Ca(2+)-mediated Mitochondrial Reactive Oxygen Species Metabolism Augments Wnt/β-Catenin Pathway Activation to Facilitate Cell Differentiation
por: Rharass, Tareck, et al.
Publicado: (2014)

Selective inhibition of intestinal guanosine 3′,5′-cyclic monophosphate signaling by small-molecule protein kinase inhibitors
por: Bijvelds, Marcel J. C., et al.
Publicado: (2018)

Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle
por: Bouzakri, Karim, et al.
Publicado: (2011)

Engagement of Nucleotide-binding Oligomerization Domain-containing Protein 1 (NOD1) by Receptor-interacting Protein 2 (RIP2) Is Insufficient for Signal Transduction
por: Mayle, Sophie, et al.
Publicado: (2014)

Spatially Restricted G Protein-coupled Receptor Activity via Divergent Endocytic Compartments
por: Jean-Alphonse, Frederic, et al.
Publicado: (2014)

Pulsatile and Sustained Gonadotropin-releasing Hormone (GnRH) Receptor Signaling: DOES THE ERK SIGNALING PATHWAY DECODE GnRH PULSE FREQUENCY?
por: Armstrong, Stephen P., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ahtcimfasoe1ehhha1r3tf1il5